Clinical Trials in Maryland

Showing 4421-4440 of 23,284 trials

Androgen Reduction in Congenital Adrenal Hyperplasia, Phase 1

NCT02574910

Children with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency tend to have elevated circulating levels of androgens, which can accelerate skeletal maturation and adversely impact adult height. Additionally, these children require supraphysiologic doses of hydrocortisone to suppress secretion of adrenal androgen precursors, and this treatment can retard linear growth. This study seeks to use oral abiraterone acetate (Zytiga)as an adjunct to approved CAH therapy (oral hydrocortisone and fludrocortisone) for pre-pubescent children with classic 21-hydroxylase deficiency in order to reduce daily requirement of hydrocortisone. In this Phase 1 study, the investigators will determine the minimum effective dose of abiraterone acetate that normalizes androstenedione levels during the 7-day Treatment Period.

Congenital Adrenal Hyperplasia

University of Texas Southwestern Medical Center4 participantsStarted Aug 2017

Los Angeles, California, United States • Bethesda, Maryland, United States • Ann Arbor, Michigan, United States +1 more locations

Active Not RecruitingPhase 217 miles

A Phase 2b, Randomized, Double-blind, Active-controlled Study of Single Dose CVXGA Intranasal COVID-19 Vaccine in Adults

NCT06742281

The purpose of this trial is to assess the safety and relative efficacy of CVXGA (CVXGA50), a KP.2 containing vaccine, compared to COMIRNATY® (COVID-19 Vaccine, mRNA; 2024-2025 Formula), a currently approved COVID-19 vaccine in the prevention of symptomatic, RT-PCR-confirmed SARS-CoV-2 infection. The trial will enroll up to 434 healthy participants.

COVID-19

CyanVac LLC432 participantsStarted Dec 2024

Anniston, Alabama, United States • Phoenix, Arizona, United States • Chula Vista, California, United States +52 more locations

Androgen Reduction in Congenital Adrenal Hyperplasia, Phase 1

A Phase 2b, Randomized, Double-blind, Active-controlled Study of Single Dose CVXGA Intranasal COVID-19 Vaccine in Adults

Find Trials by Condition in Maryland

Pediatric Radiation Therapy Registry

Ending the HIV Epidemic Through Point-of-Care Technologies (EHPOC)

AdapTive Personalized Dietitian coacHing, Messaging and pRoduce prescrIption to improVE Healthy Dietary Behaviors

A Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL)

Study of HQP1351 in Subjects With Refractory CML and Ph+ ALL

The Natural History of TRPV4 Neuropathy

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

A proof-of Concept Study to Assess Safety and Tolerability of HM15421/GC1134A in Patients With Fabry Disease

Long Term Follow-up Study of Type-1 Gaucher Subjects Post FLT201 Dose (GALILEO-2)

Phase III Trial to Investigate Efficacy and Safety of Vilobelimab in Ulcerative Pyoderma Gangrenosum

A Study of LY3405105 in Participants With Advanced Cancer

DNA Sequencing-Based Monitoring of Minimal Residual Disease to Predict Clinical Relapse in Aggressive B-cell Non-Hodgkin Lymphomas

ALTERRA Post-Approval Study

Randomized Study Comparing Two Dosing Schedules for Hypofractionated Image-Guided Radiation Therapy

Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults

Sex-specific Risk Factors and Trajectories of Blood Biomarkers for Alzheimer's Disease and Related Dementias

Pilot Trial of Mobile Technology for Adolescent Suicidality

A Clinical Study on New Negative Pressure Wound Therapy Dressing in the Management of Chronic & Acute Wounds