Effect of Biosynthetic Growth Hormone and/or Ethinyl Estradiol on Adult Height in Patients With Turner Syndrome

Exclusion Criteria

• •Patients who have received any form of human growth hormone within the past 3 months, or who have received a cumulative course of therapy totaling greater than one year.
• •Patients who have received treatment with estrogen or androgen in the past three months or who have received a cumulative course of therapy totaling greater than one year.
• •Patients who have any Y component in their chromosome analysis.
• •Patients with a chronologic age greater than 12 years.
• •Patients with a bone age greater than 12 years.
• •Patients who have clinically significant cardiac, pulmonary, gastrointestinal, hepatic or renal disease or who have had any malignancy.
• •Patients who have significant hematuria or proteinuria in pretherapy evaluation.
• •Patients who have diabetes mellitus.
• •Patients who have any active chronic infection (tuberculosis).
• •Patients who are taking amphetamines or any other drugs known to interfere with growth hormone secretion or actions.
• •Patients who are poor medical, psychological, or psychiatric risks for whom, in the opinion of the principal investigator, the investigational drug would be unwise.
• •Patients whose parents are substance abusers, nor those who come from homes in which appropriate emotional development may be limited.
• •Patients who cannot be seen on the schedule required by the protocol.