Clinical Trials in Los Angeles

Showing 2041-2060 of 8,055 trials

Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease

NCT02675959

This is a follow-up trial to NYMC 526 (NCT01461837) to assess the safety, efficacy and toxicity of administering Defibrotide prophylaxis for high-risk sickle cell or beta thalassemia patients undergoing a familial haploidentical allogeneic stem cell transplantation with CD34 enrichment and T-cell addback. This patient population historically has a risk of developing sinusoidal obstructive syndrome (SOS) and Defibrotide has demonstrated efficacy in treatment of SOS. The Funding Source is FDA OOPD.

Sickle Cell Disease

New York Medical College40 participantsStarted Jul 2017

Los Angeles, California, United States • Gainesville, Florida, United States • Valhalla, New York, United States +1 more locations

COMPLETEDPhase 3< 1 mile

A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy

NCT04349072

This is a randomized, double-blind, placebo-controlled, multi-center study in the United States (U.S.) that will evaluate the effect of mavacamten treatment on reducing the number of septal reduction therapy (SRT) procedures performed in subjects with symptomatic obstructive hypertrophic cardiomyopathy (oHCM \[also known as HOCM\]) who are eligible for SRT based on ACCF/AHA 2011 and/or ESC 2014 guidelines.

HOCM, Hypertrophic Obstructive Cardiomyopathy

Bristol-Myers Squibb112 participantsStarted Jul 2020

Los Angeles, California, United States • Stanford, California, United States • New Haven, Connecticut, United States +18 more locations

Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease

A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy

Find Trials by Condition in Los Angeles

Hybrid Coronary Revascularization Trial

Assessing the Accuracy of Tumor Biopsies After Chemotherapy to Determine if Patients Can Avoid Breast Surgery

Clinical Study to Compare Two Skin Substitute Categories for Their Effectiveness to Treat Diabetic Foot Ulcers

Mycobacteriophage Treatment of Non-tuberculosis Mycobacteria

Population Health Approach to Optimizing Medications in Older Adults

Oxandrolone Multiligament Knee

Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus

Parkinson's Foundation PD GENEration Genetic Registry

Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

Safety and Efficacy Study of CFI-402411 in Subjects With Advanced Solid Malignancies

Efficacy & Safety of rAd-IFN Administered With Celecoxib & Gemcitabine in Patients With Malignant Pleural Mesothelioma

Phase 1 Study of OLX-07010 in Healthy Adult and Elderly Participants

Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC

Outer Thigh Study With Varied Treatment Parameters

Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)

A Study of the Drugs AGN-242428 and AGN-231868 in Participants With Dry Eye Disease

StimRouter Registry Clinical Protocol

Study of Safety, Tolerability and Efficacy of PBGM01 in Pediatric Participants With GM1 Gangliosidosis