Characterization of Methylation Patterns in Cancer and Non-Cancer cfDNA

Exclusion Criteria

• •1. Known prior diagnosis of cancer except of:
• •1. Fully resected non-melanoma skin cancer
• •2. History of the original cancer in cases of recurrent disease.
• •2. Current co-diagnosis of another type of cancer.
• •3. Currently receiving, or ever received, any of the following therapies to treat their current cancer: surgical management of the cancer beyond that required to establish the cancer diagnosis; local, regional or systemic chemotherapy including chemoembolization; targeted therapy, immunotherapy including cancer vaccines; hormone therapy; or radiation therapy
• •4. Pregnancy (by self-report)
• •5. Current febrile illness
• •6. Acute exacerbation or flare of an inflammatory condition requiring escalation in medical therapy within 14 days prior to blood draw.
• •7. Recipient of organ transplant or prior non-autologous (allogeneic) bone marrow or stem cell transplant
• •1. Known current or prior diagnosis of cancer except of fully resected non-melanoma skin cancer
• •2. Currently in work-up due to suspicion of cancer of any kind
• •3. Oral or IV corticosteroid use in past 14 days prior to blood draw
• •4. Pregnancy (by self-report)
• •5. Current febrile illness
• •6. Acute exacerbation or flare of an inflammatory condition requiring escalation in medical therapy within 14 days prior to blood draw.
• •7. Recipient of organ transplant or prior non-autologous (allogeneic) bone marrow or stem cell transplant
• •8. Life expectancy \< 24 months