Clinical Trials in Illinois

Showing 4301-4320 of 14,943 trials

Testing a Family Service Navigator Program for Low-resourced Families of Young Children with Autism Spectrum Disorder

NCT05099705

The purpose of this study is to develop and test a family navigator training and an app (a technology-based treatment support system) for low-resourced families of young children (aged 3-5) with autism. The hypothesis is that the navigator training and treatment support system will help enable navigators to support families of young children with autism in accessing needed services.

Autism Spectrum DisorderMental Health Services

Vanderbilt University55 participantsStarted Jul 2022

Champaign, Illinois, United States

COMPLETEDPhase 1/2125 miles

AGEN1884, an Anti-CTLA-4 Human Monoclonal Antibody in Participants With Advanced or Refractory Cancer and Who Have Progressed With PD-1/PD-L1 Inhibitor as Their Most Recent Therapy

NCT02694822

This is an open-label, Phase 1/2, multicenter study to evaluate the safety, pharmacokinetics, and pharmacodynamics of an anti-cytotoxic T lymphocyte-associated protein-4 (CTLA-4) human monoclonal antibody (zalifrelimab) in participants with advanced or refractory cancer and in participants who have progressed during treatment with a programmed cell death protein-1/programmed cell death ligand-1 (PD-1/PD-L1) inhibitor as their most recent therapy. The phase 1 portion of the study has been completed; it enrolled adult participants with refractory, advanced cancer in a 3+3 dose escalation cohort. The phase 2 portion consisted of 51 participants who progressed during treatment with an approved or investigational PD-1/PD-L1 inhibitor as their most recent therapy (2-6 weeks prior to first dose of study drug).

Advanced Solid CancersAdvanced Solid Cancers Refractory to PD-1 and PD-L1 Therapies

Agenus Inc.89 participantsStarted Apr 2016

Duarte, California, United States • Los Angeles, California, United States • Denver, Colorado, United States +8 more locations

Testing a Family Service Navigator Program for Low-resourced Families of Young Children with Autism Spectrum Disorder

AGEN1884, an Anti-CTLA-4 Human Monoclonal Antibody in Participants With Advanced or Refractory Cancer and Who Have Progressed With PD-1/PD-L1 Inhibitor as Their Most Recent Therapy

Find Trials by Condition in Illinois

p53 Suppressor Activation in Recurrent High Grade Serous Ovarian Cancer, a Phase Ib/II Study of Systemic Carboplatin Combination Chemotherapy With or Without APR-246

A Study Evaluating the Safety and Efficacy of Lovo-cel in Severe Sickle Cell Disease

Clinical Trial to Evaluate Safety and Efficacy of CCX168 in ANCA-Associated Vasculitis

Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS)

Brain Injury Rehabilitation Improving the Transition Experience

Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function

Angio-IMR and Cardiac MR-derived MVO in STEMI Patients

WAveCrest Vs. Watchman TranssEptal LAA Closure to REduce AF-Mediated STroke 2

A Phase 1/2 Trial of CLN-081 in Patients With Non-Small Cell Lung Cancer

A Study of INCB050465 in Relapsed or Refractory Follicular Lymphoma

SNV1521 in Participants with Advanced Solid Tumors

HPV Vaccine Intervention for Young Sexual Minority Men

Open-Label Study to Evaluate Safety and Efficacy of CCX168 in Subjects With IGA Nephropathy on Stable RAAS Blockade

ALXN1210 Versus Eculizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Eculizumab

Safety and Immunogenicity of HIL-214 With Routine Pediatric Vaccines

An Evaluation of LEO 138559 in Adults With Moderate to Severe Atopic Dermatitis.

Intervention to Enhance PrEP Persistence

Pivotal, Clinical Study for the Accuracy Evaluation of the IdentiClone Dx TRG Assay