A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SAGE-718 Oral Solution in Patients With Huntington's Disease - Part B

Exclusion Criteria

• •1. Subject has any clinically significant abnormal finding on the physical exam at screening or admission.
• •2. Subject has a history or presence of a neurologic disease or condition (other than Huntington's disease), including but not limited to severe chorea, epilepsy, closed head trauma with clinically significant sequelae, or a prior seizure.
• •3. Subject has a family history of epilepsy.
• •4. Subject has a positive screening test for alcohol or drugs of abuse (including marijuana) at screening or admission.