Clinical Trials in Houston

Showing 5561-5580 of 17,885 trials

Trametinib in Treating Patients With Advanced Cancer With or Without Hepatic Dysfunction

NCT02070549

This phase I trial studies the side effects and best dose of trametinib in treating patients with cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment (advanced) with or without liver (hepatic) dysfunction. Trametinib may stop the growth of tumor cells by blocking proteins needed for cell growth. When these proteins are blocked, the growth of cancer cells may be stopped and the cancer cells will then die. Hepatic dysfunction is frequently found in patients with advanced cancer and usually prevents patients from receiving standard treatments or from participating in clinical trials. Patients may also need dose adjustments or absorb drugs differently. Trametinib may be a better treatment for patients with advanced cancers and hepatic dysfunction.

Advanced Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the LiverMetastatic Malignant Solid Neoplasm+1 more

National Cancer Institute (NCI)46 participantsStarted Mar 2014

Sacramento, California, United States • Tampa, Florida, United States • Chicago, Illinois, United States +8 more locations

COMPLETEDPhase 1/2< 1 mile

LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors

NCT04666688

A Phase 1/2 Open-label, Multi-center Study of the Safety, Pharmacokinetics, and Anti-tumor Activity of LYT-200 Alone and in Combination with Chemotherapy or Tislelizumab in Patients with Metastatic Solid Tumors

Metastatic CancerSolid TumorPancreatic Cancer+3 more

PureTech44 participantsStarted Dec 2020

Los Angeles, California, United States • Denver, Colorado, United States • Denver, Colorado, United States +9 more locations

Trametinib in Treating Patients With Advanced Cancer With or Without Hepatic Dysfunction

LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors

Find Trials by Condition in Houston

TK216 in Patients With Relapsed or Refractory Ewing Sarcoma

ATHN 7: Hemophilia Natural History Study

Selumetinib and Cyclosporine in Treating Patients With Advanced Solid Tumors or Advanced or Metastatic Colorectal Cancer

A Study of Participants with Β-Thalassemia Treated with Betibeglogene Autotemcel

A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies

A Study of Imvotamab in Severe Systemic Lupus Erythematosus

(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations

Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study

A Pivotal Study of Safety and Effectiveness of NanoKnife IRE for Stage 3 Pancreatic Cancer

A Study of AK117 in Combination With Azacitidine in Patients With Myelodysplastic Syndromes

A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Upadacitinib in Pediatric Participants With Severe Atopic Dermatitis

Artoss Prospective Spine Registry Outcomes

Surveillance and Alert-based Multiparameter Monitoring to Reduce Worsening Heart Failure Events

At-Risk for Type 1 Diabetes Extension Study (TN-10 Extension)

A Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of PGDM1400LS Alone and in Combination With VRC07-523LS and PGT121.414.LS in Healthy, HIV-uninfected Adult Participants

Non-comparative Study of IFX-1 Alone or IFX-1+Pembrolizumab in Patients With Locally Advanced or Metastatic cSCC.

A Food Additive Removal Diet for Pediatric Eosinophilic Esophagitis

Rising Tide - Amniotic Tissue(s) Treatments for Chronic Diabetic Foot Ulcers