Clinical Trials in Florida

Showing 961-980 of 12,796 trials

Pharmacokinetics and Pharmacodynamics of Subcutaneous vs Intravenous Furosemide in Healthy Volunteers

NCT06167707

This study aims to compare the pharmacokinetics and pharmacodynamics of subcutaneous (SC) and intravenous (IV) furosemide. The test formulation in this study is furosemide injection, 80 mg/1 mL, buffered to a neutral pH for SC administration via an autoinjector. A commercial formulation of furosemide injection, USP, solution 10 mg/mL administered as a 40 mg IV injection over 2 minutes followed by a second dose of 40 mg, 2 hours later, will serve as the reference drug. The objectives of this study are: * To estimate the bioavailability and describe the pharmacokinetics and pharmacodynamics of furosemide administered as SC injection via autoinjector compared with equivalent dose of furosemide administered as two 40 mg IV injections, two hours apart. * To describe the safety and tolerability of furosemide administered as SC injection via an autoinjector.

Heart FailureFluid Overload

scPharmaceuticals, Inc.21 participantsStarted Apr 2024

Tampa, Florida, United States

Active Not RecruitingPhase 349 miles

Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis

NCT04926818

Efficacy and safety of ofatumumab and siponimod compared to fingolimod in pediatric patients with multiple sclerosis

Multiple Sclerosis (MS)

Novartis Pharmaceuticals129 participantsStarted Oct 2021

Little Rock, Arkansas, United States • Los Angeles, California, United States • Washington D.C., District of Columbia, United States +48 more locations

Pharmacokinetics and Pharmacodynamics of Subcutaneous vs Intravenous Furosemide in Healthy Volunteers

Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis

Find Trials by Condition in Florida

Study of RYZ101 Compared With SOC in Pts w Inoperable SSTR+ Well-differentiated GEP-NET That Has Progressed Following 177Lu-SSA Therapy

Study of AV-1959D, an Amyloid Beta Vaccine

Partnering With Food Bank to Provide Tobacco Treatment to Underserved Smokers

A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer

AZD9291 Versus Placebo in Patients With Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy.

Study of Efficacy, Safety and Tolerability of DFV890 in Patients With Knee Osteoarthritis

A Study to Learn About Medicine Called Ritlecitinib in Children Aged Between 6 to 12 Years With Severe Alopecia Areata

Combination Study of SV-BR-1-GM With Retifanlimab

A Study of BIIB067 (Tofersen) Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation

Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma

Study of ABBV-383 Assessing Adverse Events and Clinical Activity With Subcutaneous (SC) Injection in Adult Participants With Relapsed or Refractory Multiple Myeloma

Evaluation of CRS3123 vs. Oral Vancomycin in Adult Patients With Clostridioides Difficile Infection

A Platform Study in Non-Small Cell Lung Cancer (NSCLC)

Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age

A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer

A Study of Vosoritide Versus Placebo in Children With Hypochondroplasia Aged 0 to < 36 Months