Lead Sponsor

Hoffmann-La Roche

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

No

•Diagnosed with UC for at least 12 weeks prior to screening
•Screening colonoscopy for colorectal cancer conducted within the prior two years if a history of pancolitis with disease duration ≥ 8 years or history of left-sided colitis and disease duration ≥12 years
•Evidence of disease activity at time of screening
•Insufficient clinical response to standard of care (SOC) therapy or intolerance to SOC

•Diagnosis of Crohn's disease or indeterminate colitis
•History of infection with hepatitis B, human immunodeficiency virus (HIV), active hepatitis C virus (HCV) infection, or other chronic infection
•Active infections requiring systemic therapy with antibiotic, antiviral or antifungal or febrile illness within 7 days before Day -1
•History of primary or acquired immunodeficiency
•Abnormal hematologic values
•Abnormal hepatic enzyme or hepatic function values