Clinical Trials in Detroit

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Identification of Biomarkers for Early Detection of Pancreatic Cancer

NCT00897494

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is examining blood samples from patients with cancer to identify biomarkers that may help in the early detection of pancreatic cancer.

Pancreatic Cancer

Barbara Ann Karmanos Cancer Institute75 participantsStarted Feb 2005

Detroit, Michigan, United States

COMPLETEDPhase 2< 1 mile

Selumetinib and Akt Inhibitor MK2206 or mFOLFOX Therapy Comprising Oxaliplatin and Fluorouracil in Treating Patients With Metastatic Pancreatic Cancer Previously Treated With Chemotherapy

NCT01658943

This randomized phase II trial studies how well selumetinib and Akt inhibitor MK2206 work compared to modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX) therapy in treating patients with metastatic pancreatic cancer previously treated with chemotherapy. Selumetinib and Akt inhibitor MK2206 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as oxaliplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet know whether selumetinib and Akt inhibitor MK2206 are more effective than oxaliplatin and fluorouracil in treating patients with metastatic pancreatic cancer.

Pancreatic Acinar Cell CarcinomaPancreatic Ductal AdenocarcinomaRecurrent Pancreatic Carcinoma+1 more

National Cancer Institute (NCI)137 participantsStarted Aug 2012

Tucson, Arizona, United States • Tucson, Arizona, United States • Little Rock, Arkansas, United States +531 more locations

Identification of Biomarkers for Early Detection of Pancreatic Cancer

Selumetinib and Akt Inhibitor MK2206 or mFOLFOX Therapy Comprising Oxaliplatin and Fluorouracil in Treating Patients With Metastatic Pancreatic Cancer Previously Treated With Chemotherapy

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