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Michigan Center for Pancreatic Cancer Molecular Diagnosis: The Serum Protein Microarray Project
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is examining blood samples from patients with cancer to identify biomarkers that may help in the early detection of pancreatic cancer.
OBJECTIVES: * Identify specific proteins of interest to evaluate for their potential role as markers for pancreatic cancer. * Analyze serum proteins directly by mass spectrometry to identify new biomarkers of pancreatic cancer that can be used for early diagnosis. OUTLINE: Blood from patients is collected prior to treatment. Plasma proteins are analyzed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS) and/or electrospray mass spectrometry (ESI/MS). PROJECTED ACCRUAL: A total of 120 patients will be accrued for this study.
Age
18 - 120 years
Sex
ALL
Healthy Volunteers
No
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, United States
Start Date
February 1, 2005
Primary Completion Date
November 1, 2009
Completion Date
April 1, 2011
Last Updated
March 9, 2016
75
ACTUAL participants
protein expression analysis
GENETIC
laboratory biomarker analysis
OTHER
mass spectrometry
OTHER
surface-enhanced laser desorption/ionization-time of flight mass spectrometry
OTHER
Lead Sponsor
Barbara Ann Karmanos Cancer Institute
Collaborators
NCT05053971
NCT04550494
Data Source & Attribution
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