Clinical Trials in Cleveland

Showing 1761-1780 of 19,775 trials

A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

NCT07029399

The goal of this open-label dose escalation and expansion study is to evaluate the safety and tolerability of NKT5097 in adults with advanced/metastatic tumors (emphasis on breast cancer and solid tumors with CCNE1 amplification). Main questions to answer include: * What is the recommended dose for expansion and/or Phase 2 * What medical issues/symptoms do participants experience when taking NKT5097

HR+ Breast CancerTriple Negative Breast Cancer (TNBC)CCNE1 Amplified Advanced Solid Tumors+4 more

NiKang Therapeutics, Inc.205 participantsStarted Mar 2025

La Jolla, California, United States • Denver, Colorado, United States • New Haven, Connecticut, United States +11 more locations

RECRUITINGPhase 1/2< 1 mile

A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

NCT07070232

This study will evaluate the safety, efficacy, optimal dose, and pharmacokinetics (PK) of BNT326 as monotherapy (Part 1) and as combination treatment with immunotherapeutic agents (Part 2) in participants with histologically or cytologically confirmed solid tumors that are advanced (i.e., either metastatic or recurrent tumors with no further definitive treatment possible) and/or have relapsed/progressed after prior therapy.

Advanced Solid Tumor

BioNTech SE980 participantsStarted Aug 2025

San Francisco, California, United States • Hartford, Connecticut, United States • New Haven, Connecticut, United States +50 more locations

A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

Find Trials by Condition in Cleveland

CLEANer Aspiration for Pulmonary Embolism

A Study of an Intermittent ADT Approach With Apalutamide Monotherapy in Participants With mCSPC

Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus

Study to Assess the Adverse Events of Oral ABBV-932 in Adult Participants With Depressive Episodes Associated With Bipolar I or II Disorder

Multicenter Single-arm Trial to Investigate Clinical Outcomes When Cohealyx™ is Used for Full Thickness Wounds

A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis

Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

A Study of Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

A Study of Dotinurad Versus Allopurinol in Participants With Gout

A Study to Assess the Efficacy and Safety of Afimkibart (RO7790121) in Participants With Moderate to Severe Atopic Dermatitis

Study Evaluating the Efficacy and Safety of Povorcitinib in Adults With Chronic Spontaneous Urticaria

Study of Efficacy and Safety of LXH254 Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma

Autus Valve Continued Access Study (CAS)

Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Breast Cancers

CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's Sarcoma

Improving the Quality of Care for Asthma Patients at Risk of Exacerbations

The LIFT-ECHO Last Mile Project

Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform