Clinical Trials in Cleveland

Showing 961-980 of 9,497 trials

Sternal Plating High Risk

NCT06660186

Participants are being invited to participate in a research study at University Hospitals because they have heart disease and are scheduled for open heart surgery. Currently, UH cardiac surgeons close the sternum (or breastbone) after a sternotomy (procedure that allows a doctor to reach the heart and blood vessels) with either a rigid plate fixation Sternal Plate or a Wire Cerclage. However, the study team would like to further evaluate these two techniques. Any volunteer over the age of 18 who is at an increased risk for developing sternal wound complications may be eligible to participate.

Heart Diseases

University Hospitals Cleveland Medical Center250 participantsStarted Feb 2026

Cleveland, Ohio, United States

RECRUITINGPhase 2< 1 mile

Integrated Therapies for Alcohol Use in Alcohol-associated Liver Disease (ITAALD) Trial

NCT07060638

This is a multicenter, randomized, double-blinded, placebo-controlled trial focused on the treatment of severe alcohol-associated hepatitis (sAH) and alcohol use disorder (AUD). The primary purpose of the study is to determine whether subjects receiving sAH therapy in addition to AUD treatments will have better alcohol and liver-related outcomes at 6 months compared to sAH therapy plus usual care for AUD. Patients assigned to the AUD treatment will receive Acamprosate and counseling whereas those assigned to AUD standard care will receive brief advice and referral to a 12-step program. The secondary purpose of the study is to determine if F-652 is safe and effective in treating sAH when compared to prednisone. Subjects will receive F-652 on days 1 and 7 or prednisone for 28 days. Outcomes will be measured by overall survival at 90 days.

Alcohol-associated Hepatitis

Samer Gawrieh216 participantsStarted Jan 2026

Indianapolis, Indiana, United States • Louisville, Kentucky, United States • Rochester, Minnesota, United States +3 more locations

Sternal Plating High Risk

Integrated Therapies for Alcohol Use in Alcohol-associated Liver Disease (ITAALD) Trial

Find Trials by Condition in Cleveland

A Study to Evaluate the Efficacy and Safety of ABC008 for Inclusion Body Myositis

Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD

A Study of a Novel Iron-based Phosphate Binder AP301 in Patients With Hyperphosphatemia in the U.S. and China

A Study With CIT-013 in HS Patients

Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)

Study to Compare Efficacy, Safety, and Immunogenicity of LUBT010 (Proposed Ranibizumab Biosimilar) and Lucentis® in Patients With Neovascular AMD

Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms

Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs

Prospective Study Evaluating the Treatment Outcomes for Localised Recurrent, Resectable Retroperitoneal Liposarcoma

Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.

Clinical Study of a Vaginal Cooling Device for the Treatment of Vulvovaginal Candidiasis (VVC)

Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects

A Clinical Trial of PRAX-562 in Subjects With Developmental and Epileptic Encephalopathies (DEE)

TACE With or Without SBRT as Bridging Therapy for Pre-transplant HCC Patients

Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts

Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System

BCL2i CLAG-M in R/R Acute Myeloid Leukemia

R-3750 in Patients With Mild to Moderate Ulcerative Colitis