Clinical Trials in Cleveland

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Neoadjuvant Chemoradiation Plus Pembrolizumab Followed By Consolidation Pembrolizumab in NSCLC

NCT02987998

The purpose of this study is to determine the feasibility and evaluate the safety of delivering chemoradiotherapy, the usual approach to non-small cell lung cancer, in combination with pembrolizumab (MK-3745), followed by consolidation pembrolizumab after surgical resection. Consolidation therapy is treatment given following the initial treatment. Pembrolizumab is an investigational drug (also known as Keytruda), which has been approved by the FDA for use in certain types of skin cancer (melanoma), and for use in certain types of head and neck cancer. However, it has not been approved for use in other cancers such as non-small cell lung cancer (NSCLC). Pembrolizumab is a monoclonal antibody that binds to the surface of some cells of the immune system and activates them against cancer cells. It is not chemotherapy.

Stage IIIA Non-Small Cell Lung Cancer

Nathan Pennell, MD, PhD9 participantsStarted May 2017

Cleveland, Ohio, United States

Active Not RecruitingNA< 1 mile

The LEADLESS II IDE Study for the Aveir VR Leadless Pacemaker System

NCT04559945

prospective, non-randomized, multi-center, international clinical study is designed to confirm the safety and effectiveness of the Aveir LP System in a subject population indicated for a VVI(R) pacemaker.

Cardiac Rhythm DisorderBradycardia

Abbott Medical Devices326 participantsStarted Nov 2020

Birmingham, Alabama, United States • Huntsville, Alabama, United States • Scottsdale, Arizona, United States +50 more locations

Neoadjuvant Chemoradiation Plus Pembrolizumab Followed By Consolidation Pembrolizumab in NSCLC

The LEADLESS II IDE Study for the Aveir VR Leadless Pacemaker System

Find Trials by Condition in Cleveland

AeroVanc in the Treatment of Methicillin-resistant Staphylococcus Aureus Infection in Patients With Cystic Fibrosis

Physical Therapy Trial for Pelvic Pain

Trial to Study the Effect of CVL-231 on 24-Hour Ambulatory Blood Pressure in Participants With Schizophrenia

A Study of the Effect of Topical Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism

A Study to Test Combination Treatments in People With Advanced Renal Cell Carcinoma

Study of the Effect of a 5-Day Regimen of Study Drug on Peripheral Stem Cell Mobilization in Healthy Participants

A Study to Evaluate the Efficacy and Safety of CEP-33457 in Participants With Systemic Lupus Erythematosus (SLE)

Efficacy and Safety Study of bb2121 Versus Standard Regimens in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM)

A Phase 1b Study of the Safety of REN001 in Patients With Fatty Acid Oxidation Disorders

Evaluating the Safety and Effectiveness of an Umbilical Cord Blood Stem Cell Transplant (BMT CTN 0604)

A Study of Topical NS2 Cream to Treat Ichthyosis in Sjögren-Larsson Syndrome (SLS)

Folate Receptor Alpha Peptide Vaccine With GM-CSF Versus GM-CSF Alone in Patients With Platinum Sensitive Ovarian Cancer

Ipilimumab and Nivolumab as Adjuvant Treatment of Mucosal Melanoma

Efficacy and Tolerability Study of Two Dose Regimens of CTP-543 in Adults With Alopecia Areata

Denosumab for Prevention of Post-Teriparatide Bone Loss in Premenopausal Women With IOP

A Study Evaluating the Efficacy of Venetoclax Plus Ibrutinib in Participants With T-cell Prolymphocytic Leukemia

A Study of PRO95780 in Patients With Advanced Chondrosarcoma (APM4171g)

Pan-Asia United States PrEvention of Sudden Cardiac Death Catheter Ablation Trial