Clinical Trials in Cleveland

Showing 8081-8100 of 19,775 trials

Stimulation for Colonic Motility

NCT02641483

The investigators are testing the effect of electrical stimulation of the rectum on colonic motility. Most individuals with spinal cord injury develop neurogenic bowel dysfunction, which includes slowed colonic motility, which means that stools take longer than normal to pass through the colon. This slowed movement may result in chronic constipation and difficulty emptying the bowels. Individuals typically (without or without caregiver assistance) insert a gloved finger into the rectum and gently stretch it to improve colonic motility for a brief period to empty the bowels. The investigators hypothesize that electrically stimulating the rectum, instead of mechanically stretching it, will produce the same beneficial effect of improving colonic motility. Therefore, this study will compare the two methods. If electrical stimulation effectively improves colonic motility, then the investigator shall develop the approach as a therapeutic intervention in future studies.

Neurogenic Bowel Dysfunction

VA Office of Research and Development2 participantsStarted Jan 2019

Syracuse, New York, United States • Cleveland, Ohio, United States

COMPLETEDPhase 1/2< 1 mile

A Study of Combination Therapies With Viagenpumatucel-L (HS-110) in Patients With Non-Small Cell Lung Cancer

NCT02439450

This study will test whether vaccination with viagenpumatucel-L combined with strategies to modulate the immune response is safe for patients with non-small cell lung adenocarcinoma or squamous cell carcinoma for incurable or metastatic disease.

Non-small Cell Lung Cancer

Heat Biologics121 participantsStarted Apr 2015

Tucson, Arizona, United States • La Jolla, California, United States • Boca Raton, Florida, United States +13 more locations

Stimulation for Colonic Motility

A Study of Combination Therapies With Viagenpumatucel-L (HS-110) in Patients With Non-Small Cell Lung Cancer

Find Trials by Condition in Cleveland

Cardiovascular Safety Study of Tipifarnib in Patients With Advanced Solid Malignancies

Study to Compare Tenofovir Alafenamide (TAF) Versus Tenofovir Disoproxil Fumarate (TDF) in Participants With Chronic Hepatitis B Infection Who Are Negative for Hepatitis B e Antigen

A Phase 1/2, Open-label, Multicenter, Dose Escalation and Expansion Study of SLC-3010 Monotherapy and in Combination

Impact of Fever Prevention in Brain Injured Patients

Immune Modulators for Treating COVID-19

Evaluation of the Efficacy and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo, in Subjects With Rheumatoid Arthritis (RA) Who Were Taking an Existing Medication Called a Tumour Necrosis Factor Alpha Inhibitor But Had Active Disease

Clinical Performance of Two Reusable Silicone Hydrogel Contact Lenses

Javelin BRCA/ATM: Avelumab Plus Talazoparib in Patients With BRCA or ATM Mutant Solid Tumors

Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer

Subchondroplasty® Knee RCT

Setmelanotide for the Treatment of Early-Onset Pro-Opiomelanocortin (POMC) Deficiency Obesity

Atogepant for Prophylaxis of Migraine in Participants Who Failed Previous Oral Prophylactic Treatments.

A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors

A Study Assessing the Safety and Effectiveness of IC2000 and SPY Fluorescence Imaging Systems (SPY-PHI) in the Visualization of Lymphatic Vessels and Identification of Lymph Nodes During Sentinel Lymph Node Biopsy in Subjects With Breast Cancer

MyoVista wavECG Clinical Validation Study Versus Low e' on Echocardiogram

Study Evaluating Safety and Efficacy of UCART Targeting CS1 in Patients With Relapsed/Refractory Multiple Myeloma (MELANI-01)

A Dose-escalation Study to Evaluate the Safety and Clinical Activity of PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma

INC280 Combined With Bevacizumab in Patients With Glioblastoma Multiforme