Clinical Trials in Cleveland

Showing 6501-6520 of 15,050 trials

Pragmatic Impact of Proteomic Risk Stratification in Diabetes Mellitus

NCT05182359

Single-center, prospective, 2:1 randomized controlled parallel-group study, with an open label extension to evaluate SomaSignal Informed Medical Management (informed) versus Standard of Care (uninformed).

Type 2 Diabetes

University Hospitals Cleveland Medical Center150 participantsStarted Jan 2022

Cleveland, Ohio, United States

TERMINATEDPhase 1< 1 mile

Safety Study of SEA-CD40 in Cancer Patients

NCT02376699

This study is being done to find out if SEA-CD40 is safe and effective when given alone, in combination with pembrolizumab, and in combination with pembrolizumab, gemcitabine, and nab-paclitaxel. The study will test increasing doses of SEA-CD40 given at least every 3 weeks to small groups of patients. The goal is to find the highest dose of SEA-CD40 that can be given to patients that does not cause unacceptable side effects. Different dose regimens will be evaluated. Different methods of administration may be evaluated. The pharmacokinetics, pharmacodynamic effects, biomarkers of response, and antitumor activity of SEA-CD40 will also be evaluated.

Carcinoma, Non-Small-Cell LungCarcinoma, Squamous CellHodgkin Disease+17 more

Seagen Inc.159 participantsStarted Feb 2015

Birmingham, Alabama, United States • Scottsdale, Arizona, United States • Los Angeles, California, United States +16 more locations

Pragmatic Impact of Proteomic Risk Stratification in Diabetes Mellitus

Safety Study of SEA-CD40 in Cancer Patients

Find Trials by Condition in Cleveland

A Study Evaluating Intensive Chemotherapy With or Without Glasdegib or Azacitidine With or Without Glasdegib In Patients With Previously Untreated Acute Myeloid Leukemia

Genomic Response Analysis of Heart Failure Therapy in African Americans

Surgery to Remove the Sentinel Lymph Node and Axillary Lymph Nodes After Chemotherapy in Treating Women With Stage II, Stage IIIA, or Stage IIIB Breast Cancer

ErbB2 Over-expressing Metastatic Breast Cancer Study Using Paclitaxel, Trastuzumab, and Lapatinib

tPA by Endovascular Administration for the Treatment of Submassive PE Using CDT for the Reduction of Thrombus Burden

Efficacy, Safety, and Pharmacokinetics of APT-1011 in Subjects With Eosinophilic Esophagitis (EoE)

Efficacy and Safety of NYX-2925 in Subjects With Neuropathic Pain Associated With Diabetic Peripheral Neuropathy (DPN)

Randomized Trial in Adult Participants With Acute Migraines

A Study to Evaluate the Safety and Efficacy of VX-121 Combination Therapy in Subjects With Cystic Fibrosis

FX-322 in Adults With Stable Sensorineural Hearing Loss

Video Gaming for Home Rehabilitation for Children With Hemiplegic Cerebral Palsy in Costa Rica

Study to Determine the Efficacy, Safety, Tolerability & Pharmacokinetics of RO 205-2349 in Patients With Type 2 Diabetes Mellitus

Relative Bioavailability of LY03010 Compared to Listed Drug

A Study to Evaluate the Efficacy, Safety, and Tolerability of CBL-514 Injection for Reducing Subcutaneous Fat (Stage 2)

Rapid Diagnostics for HIV and Hepatitis

A Study of TAK-951 to Stop Adults Getting Nausea and Vomiting After Planned Surgery

A Study of TY-2136b in Patients With Advanced Solid Tumors Harboring ALK, ROS1 or NTRK1-3 Alterations

Evaluating the Safety and Immune Response to Three Different DNA HIV Vaccines Administered With a MVA-CMDR Boost Vaccine in Healthy, HIV-Uninfected Adults