Clinical Trials in Cleveland

Showing 601-620 of 19,775 trials

Mirdametinib + BGB-3245 in Advanced Solid Tumors

NCT05580770

A Phase 1/2a open-label, multicenter, dose escalation and expansion study of mirdametinib in combination with BGB-3245 in adult participants with histologically confirmed, advanced (American Joint Committee on Cancer (AJCC) Stage III or IV) metastatic or unresectable solid cancer that is refractory to or has progressed during or after at least 1 line of appropriate prior systemic anti-cancer therapy including chemotherapy, immunotherapy, or appropriate targeted therapy, or for which there is no treatment available, or prior standard of care therapy was not tolerated.

Advanced Solid Tumor

SpringWorks Therapeutics, Inc.23 participantsStarted Feb 2023

La Jolla, California, United States • New Haven, Connecticut, United States • Boston, Massachusetts, United States +5 more locations

COMPLETEDPhase 3< 1 mile

A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19

NCT05815498

The purpose of this study (Part 1 and Part 2) is to evaluate the relative vaccine efficacy (rVE), safety, reactogenicity, and immunogenicity of mRNA-1283.222 versus mRNA-1273.222 (Part 1) and mRNA-1283.815 versus mRNA-1273.815 (Part 2).

COVID-19

ModernaTX, Inc.13,553 participantsStarted Mar 2023

Huntsville, Alabama, United States • Vestavia Hills, Alabama, United States • Chandler, Arizona, United States +227 more locations

Mirdametinib + BGB-3245 in Advanced Solid Tumors

A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19

Find Trials by Condition in Cleveland

Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen

A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma

Herbs & Supplements in Breast Cancer Usage, Impact, and Personalized Approaches for Diverse Populations

A Study Evaluating Efruxifermin in Subjects With Non-invasively Diagnosed Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Nonalcoholic Fatty Liver Disease (NAFLD)/Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)

DESTINY-PANTUMOUR04

A 3-part Study of SYX-5219 in Healthy Volunteers and Participants With Atopic Dermatitis

An Extension Study of Subjects Who Received an Avalyn Inhaled Antifibrotic Agent (SAIL)

A Pivotal Safety and Efficacy Study of OCS-01 Eye Drops in Participants With Diabetic Macular Edema (DIAMOND 2)

Long-term Efficacy and Safety Extension (LTE) Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria

A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration

Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200).

Evaluate the Safety and Effectiveness of the Polymotion Hip Resurfacing (PHR) System Compared to Total Hip Arthroplasty

A Study to Assess the Effectiveness and Safety of IPN10200 Over Time in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows

ADH1 and ADH2 Disease Monitoring Study (DMS)

Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer

Saroglitazar Magnesium for Treatment of Primary Biliary Cholangitis

Combination of Serabelisib and Insulin Suppressing Diet With or Without Nab-paclitaxel in Subjects With Advanced Solid Tumors With PIK3CA Mutations