Clinical Trials in Cleveland

Showing 5001-5020 of 15,050 trials

Phase 1 Study of BAFF CAR-T Cells (LMY-920) for Non-Hodgkin Lymphoma

NCT05312801

Therapy with chimeric antigen receptor T (CAR-T) cells has demonstrated activity against refractory lymphoma, however not all tumors respond or remain in response to CD19 targeted CAR-T cells. We posit that CAR-T cells expressing BAFF (BAFF CAR-T cells) can become another strategy to treat refractory lymphoma, even after relapse following cluster of differentiation antigen 19 (CD19) targeting CAR-T treatment. This phase 1 study will evaluate safe dose and provide initial signal of the activity of BAFF CAR-T cells against relapsed non-Hodgkin lymphoma using a single lymphodepletion regimen and using a BAFF CAR-T cell manufacturing process.

Lymphoma, Non-Hodgkin Lymphoma, B-Cell

Luminary Therapeutics20 participantsStarted Nov 2023

Cleveland, Ohio, United States • Cleveland, Ohio, United States

COMPLETED< 1 mile

Hypotension Prediction Index Study (HPI Study)

NCT03805217

A prospective, single-arm, open-label, multicenter post-approval study to determine whether the use of the Acumen HPI Software to guide intraoperative hemodynamic management in non-cardiac surgery reduces the duration of intraoperative hypotension below a threshold of Mean Arterial Pressure (MAP)

Hypotension

Edwards Lifesciences485 participantsStarted May 2019

Stanford, California, United States • Aurora, Colorado, United States • New Haven, Connecticut, United States +8 more locations

Phase 1 Study of BAFF CAR-T Cells (LMY-920) for Non-Hodgkin Lymphoma

Hypotension Prediction Index Study (HPI Study)

Find Trials by Condition in Cleveland

LMY-920 for Treatment of Relapsed or Refractory Myeloma

Identifying and Treating Depression in Hemodialysis Patients

Study of Monovalent and Bivalent Recombinant Protein Vaccines Against COVID-19 in Adults 18 Years of Age and Older

Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

A 2-Part First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of CMTX-101

Comparative Effectiveness of Direct Admission & Admission Through Emergency Departments for Children

Safety and Efficacy of IMC-C103C as Monotherapy and in Combination With Atezolizumab

Study of the Safety, Pharmacokinetics and Efficacy of Tinostamustine in Patients With Advanced Solid Tumors.

SL-401 as Consolidation Therapy in Patients With Adverse Risk Acute Myeloid Leukemia in First Complete Remission

REVEAL 2 Trial (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)

Stockholm3 Validation Study in a Multi-Ethnic Cohort

Assessment of Macrophage Activation syndromE in STill's Disease

Milademetan in Advanced/Metastatic Solid Tumors

Anti-inflammatory Drugs and Serum Prostate-Specific Antigen Test

Assess Aesthetic Improvement and Onset of QM1114-DP in Subjects With Moderate to Severe Glabellar Lines

Vitamin D to Improve Outcomes by Leveraging Early Treatment: Long-term Brain Outcomes in Vitamin D Deficient Patients

Study Investigating the Safety and Efficacy of Blinatumomab in Combination With Pembrolizumab in Adults With Relapsed or Refractory Diffuse Large B Cell Lymphoma (DLBCL)

MK-2060 and Clopidogrel Co-administration Safety and Tolerability Study in Participants With End-Stage Renal Disease (ESRD) (MK-2060-008)