Clinical Trials in Cleveland

Showing 3641-3660 of 19,775 trials

hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM)

NCT05052957

This phase II trial studies the effect of P140K MGMT hematopoietic stem cells, O6-benzylguanine, temozolomide, and carmustine in treating participants with supratentorial glioblastoma or gliosarcoma who have recently had surgery to remove most or all of the brain tumor (resected). Chemotherapy drugs, such as 6-benzylguanine, temozolomide, and carmustine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing. Placing P140K MGMT, a gene that has been created in the laboratory into bone marrow making the bone more resistant to chemotherapy, allowing intra-patient dose escalation which kills more tumor cells while allowing bone marrow to survive.

Glioblastoma MultiformeGlioblastoma Multiforme, AdultSupratentorial Glioblastoma+1 more

Leland Metheny16 participantsStarted Jan 2023

Cleveland, Ohio, United States

Active Not RecruitingPhase 3< 1 mile

A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

NCT03383458

This study will investigate if nivolumab will improve recurrence-free survival (RFS) compared to placebo in participants with HCC who have undergone complete resection or have achieved a complete response after local ablation, and who are at high risk of recurrence

Hepatocellular CarcinomaLiver Cancer

Bristol-Myers Squibb545 participantsStarted Apr 2018

Anniston, Alabama, United States • Phoenix, Arizona, United States • Tucson, Arizona, United States +181 more locations

hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM)

A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

Find Trials by Condition in Cleveland

Flexible-Dose Trial in Early Parkinson's Disease (PD)

A Study to Investigate Vamikibart in Participants With Uveitic Macular Edema

Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy

Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR

Study Comparing Emergency Contraception Effectiveness in Women Who Weight ≥ 80 kg

Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors

Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis

Surgery With or Without Postoperative Intensity Modulated Radiation Therapy in Treating Patients With Urothelial Bladder Cancer

Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)

Comparison of the Human Acellular Vessel (HAV) With Fistulas as Conduits for Hemodialysis

Comparison of Transforming Powder Dressing to NPIAP Recommended Standard of Care Therapies in Stage 2, 3 and 4 Pressure Injuries

Allergic Disease Onset Prevention Study

Non-interventional Study on Osilodrostat in Patients With Endogenous Cushing's Syndrome

Gene Transfer Clinical Trial for Infantile and Late Infantile Krabbe Disease Treated Previously With HSCT

A Study of Intravesical Enfortumab Vedotin For Treatment of Patients With Non-muscle Invasive Bladder Cancer (NMIBC)

Diagnostic and Therapeutic Applications of Microarrays in Lung Transplantation

A Novel Posttraumatic Stress Disorder Treatment for Veterans With Moral Injury

The REgistry of Very Early Estrogen and AnovuLation