Clinical Trials in Cleveland

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Sequential Cystatin C Levels and Renal Impairment in Acute Heart Failure

NCT00561483

Renal Compromise after treatment of decompensated heart failure with diuretics is not uncommon. The purpose of our study is to investigate the relationship between cystatin C and worsening renal function in this setting. Cystatin C is a biomarker produced at a constant rate by all cells that is a sensitive biomarker of renal function.Cystatin C and Plasma amino terminal proB-type natriuretic peptide (NT-proBNP) levels will be obtained at baseline and daily. Our goal is to enroll 100 subjects with an estimated 5 samples per each subject. The time course of changes in cystatin C in relation to serum creatinine levels over time will be plotted. Our hypothesis is that sequential changes in cystatin C levels following initial treatment with diuretic therapy in the setting of acute decompensated heart failure may provide early insight into cardio-renal compromise. Understanding the natural history and time course of the changes in sequential cystatin C levels may facilitate further studies to guide the judicious use of diuretic therapy in acute decompensated heart failure, and to predict the risk of subsequent development of worsening renal function. If serial testing of cystatin C can provide accurate assessment and prediction of worsening renal function, clinical applications of these observations can be evaluated in future prospective studies.

Acute Heart FailureRenal Failure

The Cleveland Clinic64 participantsStarted Dec 2007

Cleveland, Ohio, United States

RECRUITINGPhase 2< 1 mile

Alteration of the Immune Microenvironment in Basal Cell Carcinoma Following Photodynamic Therapy

NCT05020912

The purpose of this study is to better understand the immune response to basal cell carcinoma (BCC) treated with Photodynamic Therapy (PDT) in order to develop new methods of treating BCC. Previous research suggests that PDT alters the immune response, possibly in a way that could promote better tumor clearance when combined with other treatments. Overall, participation in this study will help the study team better understand the anti-tumor immune response when BCC is treated with PDT.

Basal Cell Carcinoma

Case Comprehensive Cancer Center28 participantsStarted Dec 2021

Cleveland, Ohio, United States

Sequential Cystatin C Levels and Renal Impairment in Acute Heart Failure

Alteration of the Immune Microenvironment in Basal Cell Carcinoma Following Photodynamic Therapy

Find Trials by Condition in Cleveland

Implant for Walking After Incomplete SCI

Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis

Ketamine in Central Sensitization

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A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities

A Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Knee Osteoarthritis Pain.

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SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke

Re-establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease

Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease

Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

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QUILT-3.038: Active Immunotherapy CEA Vaccine in Patients With Malignancies Expressing CEA

ABX464 in Treating Inflammation and Preventing Acute Respiratory Failure in Patients With COVID-19

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