Clinical Trials in Chicago

Showing 1221-1240 of 9,860 trials

A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)

NCT06422923

This is a multicenter, single arm, open label clinical trial that is designed to test the safety and preliminary efficacy of single administration inhibitory nerve cells called interneurons (NRTX-1001), into both temporal lobes of subjects with drug-resistant bilateral mesial temporal lobe epilepsy.

Epilepsy, Temporal Lobe

Neurona Therapeutics10 participantsStarted Nov 2024

Little Rock, Arkansas, United States • Los Angeles, California, United States • Orange, California, United States +14 more locations

RECRUITING2.2 miles

A Study to Check Liver Health in Boys With XLMTM, a Serious Genetic Muscle Condition

NCT06581146

XLMTM (X-linked myotubular myopathy) is a serious genetic muscle condition. It is caused by changes in the MTM1 gene which stops or slows down normal muscle development, causing severe muscle weakness. There is currently no cure for XLMTM. Ongoing care is needed to manage symptoms and prevent further medical problems from this condition. Recent research shows that individuals with XLMTM often have reduced bile flow which can affect liver and gallbladder health. Bile is a liquid made in the liver that helps digest fat. Ongoing liver health checks may help with the routine care of people with XLMTM. There is a need to understand liver problems that develop in individuals with XLMTM over time. The main aim of the study is to learn how many boys with XLMTM have new cases of liver problems during the study. This study is about collecting information only. This is known as an observational study. The individual's doctor decides on treatment, not the study sponsor (Astellas). In this study, boys under 18 diagnosed with XLMTM will be followed for about 1 year. The health of their liver and gallbladder will be checked about every 6 weeks. This can be done at home, if preferred. A scan called a Fibroscan (also known as transient elastography) will check for signs of scarring in the liver (fibrosis) and the build-up of lipids. It is suggested that each boy will have a Fibroscan when they start the study and another scan when they complete the study. This study will help understand liver, gallbladder, and bile duct issues in individuals with XLMTM over time. The goal is to improve their care and provide information to use in future clinical studies.

X-Linked Myotubular Myopathy

Astellas Gene Therapies50 participantsStarted May 2025

Chicago, Illinois, United States • Boston, Massachusetts, United States • Cincinnati, Ohio, United States +2 more locations

A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)

A Study to Check Liver Health in Boys With XLMTM, a Serious Genetic Muscle Condition

Find Trials by Condition in Chicago

Suture Repair vs Mesh Repair for Incisional Hernia

Study of Retinfanlimab in Combination With INCAGN02385 and INCAGN02390 as First-Line Treatment in Participants With PD-L1-Positive (CPS ≥ 1) Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF

Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS

The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer

A Study of CT-388 in Participants Who Are Overweight or Obese With Type 2 Diabetes Mellitus

Comparison of Methods of Pulmonary Blood Flow Augmentation in Neonates: Shunt Versus Stent (The COMPASS Trial)

Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders

International Registry of Intra-arterial and Endosaccular Flow Diverters (IRF)

[18F]PI-2620 Phase 3 Histopathological Study

Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone

Allied Cleft & Craniofacial Quality-Improvement and Research Network (ACCQUIREnet)

RewinD-LB - Clinical Study of Neflamapimod in Patients With Dementia With Lewy Bodies

Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophy

Conservative Surgery in Treating Patients With Low-Risk Stage IA2 or IB1 Cervical Cancer

Safety and Tolerability of IPH4502 in Patients With Advanced Solid Tumors

A Phase 1b Study of Budoprutug in Systemic Lupus Erythematosus (SLE)

Roll-over Study for Patients Who Have Completed a Prior Novartis-sponsored Sabatolimab (MBG453) Study and Are Judged by the Investigator to Benefit From Continued Treatment With Sabatolimab.