Microbiota Restoration Therapy for Recurrent Clostridium Difficile-associated Diarrhea

Exclusion Criteria

• •Continued (uncontrolled) CDAD after completing a 10-14 day course of oral antibiotics.
• •Requires antibiotic therapy for a condition other than CDAD.
• •Previous fecal transplant prior to study enrollment.
• •History of inflammatory bowel disease (IBD), e.g., ulcerative colitis, Crohn's disease, or microscopic colitis.
• •History of irritable bowel syndrome (IBS).
• •History of chronic diarrhea.
• •History of celiac disease.
• •History of cirrhosis of the liver or ascites.
• •Disease symptoms caused by a confirmed intestinal pathogen other than Clostridium difficile.
• •Has a colostomy.
• •Intraabdominal surgery within the last 60 days.
• •Evidence of active, severe colitis.
• •History of short gut syndrome or motility disorders.
• •Requires the regular use of medications that affect bowel motility (e.g., metoclopramide, narcotics, loperamide).
• •Planned therapy in the next 3 months that may cause diarrhea (e.g., chemotherapy).
• •Planned surgery requiring perioperative antibiotics within 6 months of study enrollment.
• •Life expectancy of \< 12 months.
• •Compromised immune system, e.g., HIV infection (any CD4 count); AIDS-defining diagnosis or CD4 \<200/mm3; inherited/primary immune disorders; immunodeficient or immunosuppressed due to a medical condition or medication; current or recent (\< 90 days) treatment with chemotherapy; or current or recent (\< 90 days) treatment with immunosuppressant medications.
• •Taking steroids (≥ 20 mg a day) or is expected to be on steroids for more than 30 days after enrollment.
• •Neutropenia (white blood cell count \<1000 cells/µL).