Clinical Trials in Chicago

Showing 841-860 of 20,493 trials

High-Dose or Low-Dose Vorinostat in Combination With Carboplatin or Paclitaxel in Treating Patients With Advanced Solid Tumors

NCT01281176

This randomized pilot clinical trial studies high-dose or low-dose vorinostat in combination with carboplatin or paclitaxel in treating patients with advanced solid tumors. Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving different doses of vorinostat together with carboplatin or paclitaxel may kill more tumor cells.

Adult Solid Neoplasm

National Cancer Institute (NCI)20 participantsStarted Feb 2011

Chicago, Illinois, United States

Active Not RecruitingPhase 32.2 miles

A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

NCT06292013

The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin). Approximately 1700 additional participants will be enrolled in an addendum to explore Lp(a) lowering with an alternative dosing schema.

Atherosclerotic Cardiovascular Disease (ASCVD)Elevated Lp(a)

Eli Lilly and Company17,300 participantsStarted Mar 2024

Birmingham, Alabama, United States • Daphne, Alabama, United States • Dothan, Alabama, United States +930 more locations

High-Dose or Low-Dose Vorinostat in Combination With Carboplatin or Paclitaxel in Treating Patients With Advanced Solid Tumors

A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Find Trials by Condition in Chicago

A Study to Evaluate the Effectiveness of Long-acting (LA) Cabotegravir (CAB) + Rilpivirine (RPV) LA When Given to Participants With Detectable HIV-1

A Study to Assess the Effectiveness and Safety of Irinotecan Liposome Injection, 5-fluorouracil/Leucovorin Plus Oxaliplatin in Patients Not Previously Treated for Metastatic Pancreatic Cancer, Compared to Nab-paclitaxel+Gemcitabine Treatment

A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)

A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors

A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)

Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD

Ocular Assessments in Patients Treated With Tivdak® in Recurrent or Metastatic Cervical Cancer

Cognitive Training as an Adjunct to Ketamine in Real-world Clinics

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

First-in-Human Study of DS-3939a in Participants With Advanced Solid Tumors

Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia

Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBS

Dabrafenib and/or Trametinib Rollover Study

Study of DONQ52 in Active Celiac Disease

Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection

Ivosidenib, Nivolumab, and Ipilimumab Combination in Previously Treated Subjects With Nonresectable or Metastatic IDH1 Mutant Cholangiocarcinoma