Clinical Trials in Chicago

Showing 841-860 of 9,860 trials

A Study of AZD0120 in Autoimmune Diseases

NCT07295847

This trial is a Phase 1b, open-label, multi-center, clinical study of AZD0120, a BCMA/CD19 dual targeting CAR+ T-cell therapy, to evaluate the safety and tolerability in adult participants with systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM), or difficult-to-treat rheumatoid arthritis (D2T RA).

Systemic SclerosisIdiopathic Inflammatory MyopathiesRheumatoid Arthritis

AstraZeneca27 participantsStarted Jan 2026

Tucson, Arizona, United States • Stanford, California, United States • Chicago, Illinois, United States +15 more locations

ACTIVE_NOT_RECRUITINGPHASE32.2 miles

S1207 Hormone Therapy With or Without Everolimus in Treating Patients With Breast Cancer

NCT01674140

RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen citrate, goserelin acetate, leuprolide acetate, anastrozole, letrozole, or exemestane, may fight breast cancer by lowering the amount of estrogen the body makes. Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet know whether hormone therapy is more effective when given with or without everolimus in treating breast cancer. PURPOSE: This randomized phase III trial studies how well giving hormone therapy together with or without everolimus work in treating patients with breast cancer.

Breast Cancer

SWOG Cancer Research Network1,939 participantsStarted Sep 2013

Birmingham, Alabama, United States • Anchorage, Alaska, United States • Anchorage, Alaska, United States +1456 more locations

A Study of AZD0120 in Autoimmune Diseases

S1207 Hormone Therapy With or Without Everolimus in Treating Patients With Breast Cancer

Find Trials by Condition in Chicago

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

A Phase 1/2 Trial of ARV-471 Alone and in Combination With Palbociclib (IBRANCE®) in Patients With ER+/HER2- Locally Advanced or Metastatic Breast Cancer

Amplatzer Amulet LAAO vs. NOAC

Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer

A Study to Evaluate the Efficacy and Safety of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa

RENAL: TNF-alpha Inhibitor for Improving Renal Dysfunction and Primary Graft Dysfunction After Lung Transplant

A Study to Learn About BNT162b2 (LP.8.1)-Adapted Vaccine Against SARS-CoV-2 in Children 5 Through 11 Years of Age That Are Considered at Higher Risk of Severe COVID-19

Registry of Patients With AQP4+ NMOSD Treated With Alexion C5 Inhibitor Therapies

Study of INCB123667 in Subjects With Advanced Solid Tumors

Galleri® in the Medicare Population.

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS)

The Golazo® Peripheral Atherectomy System for a Safe and Effective Atherectomy (GREAT Trial)

Study of ATX-01 in Participants With DM1

Maternal-fetal Immune Responses to Fetal Surgery

Osimertinib Plus Savolitinib in EGFRm+/MET+ NSCLC Following Prior Osimertinib

Shared Decision Making to Improve Goals of Care in the ED

EMUs: Enhanced Monitoring Using Sensors After Surgery