Clinical Trials in Chicago

Showing 641-660 of 20,493 trials

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

NCT04468061

This research study involves testing the safety and efficacy of an investigational intervention for patients with triple-negative breast cancer (TNBC) that has spread, or metastasized, to other parts the body and is PD-L1-negative. The names of the study interventions involved in this study are: * Sacituzumab govitecan (Trodelvy™;IMMU-132) * Pembrolizumab (Keytruda®; MK-3475)

Breast CancerTriple Negative Breast CancerPD-L1 Negative

Dana-Farber Cancer Institute110 participantsStarted Jul 2020

Stamford, Connecticut, United States • Miami, Florida, United States • Plantation, Florida, United States +12 more locations

Active Not RecruitingPhase 22.2 miles

Paclitaxel With or Without Cixutumumab as Second-Line Therapy in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer

NCT01142388

This randomized phase II trial studies how well paclitaxel with or without cixutumumab works in treating patients with esophageal cancer or gastroesophageal junction cancer that has spread to other places in the body (metastatic). Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cixutumumab may kill cancer cells by blocking the action of a protein needed for cancer cell growth. Giving paclitaxel with or without cixutumumab may kill more tumor cells.

Metastatic Esophageal AdenocarcinomaMetastatic Esophageal Squamous Cell CarcinomaMetastatic Gastroesophageal Junction Adenocarcinoma+5 more

National Cancer Institute (NCI)94 participantsStarted Sep 2010

Scottsdale, Arizona, United States • Palo Alto, California, United States • Aurora, Colorado, United States +230 more locations

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

Paclitaxel With or Without Cixutumumab as Second-Line Therapy in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer

Find Trials by Condition in Chicago

SAGE LEAF 2: An Online Program to Reduce Dementia Caregiver Burden

Efficacy and Safety of Seralutinib in Adult Subjects With PAH (PROSERA)

Decitabine in Treating Patients With Myelofibrosis

Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

VE303 for Prevention of Recurrent Clostridioides Difficile Infection

An Active-Controlled Early Phase Study of Elpipodect (MK-8189) in Adults With Schizophrenia (MK-8189-005)

A Prospective Trial of a Variable Compression System for Moderate to Severe Irritable Bowel Syndrome

Extended-release Buprenorphine Compared to Sublingual Buprenorphine in Rural Settings (RXR)

Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN

Protocol for Collecting, Banking and Distributing Human Tissue Samples: St. Jude Children's Research Hospital Tissue Resources Core Facility

A Study to Learn About How a New Pneumococcal Vaccine Works in Infants

Open-Label Study of AB-729, Nucleos(t)Ide Analogue and Pegylated Interferon Alfa-2a in Subjects With Chronic Hepatitis B Infection

Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma

A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)

Digital Bonding vs. Direct Bonding Study

Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

Tensi+ for Treating Overactive Bladder

A Proof-of-concept Study of Lunsekimig Compared With Placebo in Adults With Chronic Rhinosinusitis With Nasal Polyps