Clinical Trials in Chicago

Showing 6081-6100 of 20,493 trials

Safety and Activity Study of an Oral Medication to Treat Moderate to Severe Crohn's Disease

NCT00102921

The purpose of this research study is to investigate the effects of an investigational medication, called CCX282-B, on safety and on the some of the symptoms of Crohn's Disease in patients who are experiencing an active flare-up of moderate to severe Crohn's Disease.

Crohn Disease

Amgen70 participantsStarted Aug 2004

Los Angeles, California, United States • Golden, Colorado, United States • Littleton, Colorado, United States +11 more locations

COMPLETEDPhase 12.2 miles

MGD019 DART® Protein in Unresectable/Metastatic Cancer

NCT03761017

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics (PK) pharmacodynamics and preliminary antitumor activity of lorigerlimab. This Phase 1, open-label study will characterize safety, dose-limiting toxicities (DLTs), and maximum tolerated/administered dose (MTD/MAD) of MGD019. Dose escalation will occur in a 3+3+3 design in patients with advanced solid tumors of any histology. Once the MTD/MAD is determined, a Cohort Expansion Phase will be enrolled to further characterize safety and initial anti-tumor activity in patients with specific tumor types anticipated to be sensitive to dual checkpoint blockade.

Squamous Cell Non Small Cell Lung CancerProstate Cancer MetastaticCutaneous Melanoma+3 more

MacroGenics162 participantsStarted Dec 2018

Chicago, Illinois, United States • Boston, Massachusetts, United States • Boston, Massachusetts, United States +36 more locations

Safety and Activity Study of an Oral Medication to Treat Moderate to Severe Crohn's Disease

MGD019 DART® Protein in Unresectable/Metastatic Cancer

Find Trials by Condition in Chicago

A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression

SCS as an Option for Chronic Low Back and/or Leg Pain Instead of Surgery

P-CHAT: Comparison of Direct to Consumer Delivery Models for Hearing Devices

Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event (HFpEF Decompensation) Who Have Been Stabilized and Initiated at the Time of or Within 30 Days Post-decompensation (PARAGLIDE-HF)

A Study to Evaluate the Anti-inflammatory Effects of Letermovir (Prevymis) in Adults With Human Immunodeficiency Virus (HIV)-1 and Asymptomatic Cytomegalovirus (CMV) Who Are on Suppressive Antiretroviral Therapy, Plus Its Effect on Chronic Inflammation, HIV Persistence and Other Clinical Outcomes.

Maintenance NeuroStar Transcranial Magnetic Stimulation (TMS) in Patients With Major Depressive Disorder

LEO 124249 Ointment in the Treatment of Alopecia Areata

LEO 90100 Compared With Calcipotriol Plus Betamethasone Dipropionate Ointment, LEO 90100 Vehicle and Ointment Vehicle in Subjects With Psoriasis Vulgaris

Study of EYP-1901 in Patients With Diabetic Macular Edema (DME)

Observational Study of Persistence on Bafiertam Treatment in Routine Clinical Practice

AZithromycin Therapy in Preschoolers With a Severe Wheezing Episode Diagnosed at the Emergency Department

Study of Lanreotide Autogel in Non-functioning Entero-pancreatic Endocrine Tumours

A Study of Increasing Strengths, Safety and Efficacy of Two Formulas of LEO 43204 on the Face or the Chest in Patients With Actinic Keratosis

An Epidemiological Study to Assess Performance of Using Healthcare Tools to Understand Genital Herpes Simplex Virus-2 (HSV-2) in Patients ≥ 18 Years of Age in the United States and Europe.

Rapid On Site Evaluation of Pleural Touch Preparations in Diagnosing Malignant Pleural Effusion in Patients Undergoing Pleuroscopy

Open Label Pharmacokinetic Study of SAR302503 in Subjects With Renal Impairment

A Study of JNJ-80038114 in Participants With Advanced Stage Prostate Cancer

T-DM1+Pertuzumab in Pre-OP Early-Stage HER2+ BRCA