Clinical Trials in Chicago

Showing 2701-2720 of 9,860 trials

Transcutaneous Spinal Cord Stimulation in Healthy Adults

NCT06116838

The goal of this study is to understand how transcutaneous spinal cord stimulation (tSCS) waveform, modulation frequency, and stimulation location impact lower extremity muscle activation and participant comfort in adults without neurologic conditions.

Healthy Adults

Shirley Ryan AbilityLab50 participantsStarted Oct 2025

Chicago, Illinois, United States

Active Not RecruitingPhase 12.2 miles

Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 Mutation

NCT02632708

The purpose of this Phase I, multicenter, clinical trial is to evaluate the safety of AG-120 and AG-221 when given in combination with standard AML induction and consolidation therapy. The study plans to evaluate up to 2 dose levels of AG-120 in participants with an isocitrate dehydrogenase protein 1 (IDH1) mutation and up to 2 dose levels of AG-221 in participants with an isocitrate dehydrogenase protein 2 (IDH2) mutation. AG-120 or AG-221 will be administered with 2 types of AML induction therapies (cytarabine with either daunorubicin or idarubicin) and 2 types of AML consolidation therapies (mitoxantrone with etoposide \[ME\] or cytarabine). After consolidation therapy, participants may continue on to maintenance therapy and receive daily treatment with single-agent AG-120 or AG-221 until relapse, development of an unacceptable toxicity, or hematopoietic stem cell transplant (HSCT). The study will end when all participants have discontinued study treatment.

Newly Diagnosed Acute Myeloid Leukemia (AML)Untreated AMLAML Arising From Myelodysplastic Syndrome (MDS)+2 more

Institut de Recherches Internationales Servier153 participantsStarted Dec 2015

Duarte, California, United States • Los Angeles, California, United States • Aurora, Colorado, United States +14 more locations

Transcutaneous Spinal Cord Stimulation in Healthy Adults

Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 Mutation

Find Trials by Condition in Chicago

Pulmonary Fibrosis Foundation Community Registry

Study to Evaluate the Efficacy of a Probiotic in Infantile Colic Symptoms Relief

Evaluation of TEACH (Training Early Achievers for Careers in Health) Research

Long-term Follow-up of Subjects With Transfusion-Dependent β-Thalassemia (TDT) Treated With Ex Vivo Gene Therapy

REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma

Study of Efficacy of CML-CP Patients Treated With ABL001 Versus Bosutinib, Previously Treated With 2 or More TKIs

Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD

ASPIRE: Adapting Self-Blood Pressure Monitoring to Reduce Health Disparities

Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer

AB-1002 in Patients With Class III Heart Failure

Comparing Ankle Fusion to Ankle Replacement

Ureteral Stent Placement After Ureteroscopy for Renal Stones: A Randomized Controlled Trial

The ME&MG Digital Solution for Autonomous Assessment of Myasthenia Gravis

Amivantamab in Adenoid Cystic Carcinoma

A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV)

Study of Efficacy, Safety and Tolerability of CMK389 in Patients With Chronic Pulmonary Sarcoidosis

Safety and Tolerability of BION-1301 in Healthy Volunteers and Adults With IgA Nephropathy (IgAN)

BAsel Syncope EvaLuation (BASEL IX) Study