Clinical Trials in Baltimore

Showing 19181-19200 of 23,476 trials

Efficacy of Bevacizumab (Avastin) in Treatment of Acute NMO Exacerbations

NCT01777412

This is a phase 1b interventional trial of bevacizumab (Avastin®) to evaluate the tolerability/safety and preliminary efficacy of bevacizumab (Avastin®) as add-on therapy for treatment of acute optic neuritis and/or transverse myelitis in neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD). A single infusion of Avastin® is added to standard-of-care high dose steroids and an additional dose of Avastin® is added to plasma exchange (if necessary). The primary outcomes are clinical changes in the Expanded Disability Severity Scale, Timed 25-foot Walk and Low Contrast Visual Acuity, MRI parameters and safety.

Neuromyelitis OpticaNeuromyelitis Optica Spectrum Disorder

Johns Hopkins University10 participantsStarted Jun 2013

Baltimore, Maryland, United States

COMPLETEDPhase 1< 1 mile

Evaluating the Safety and Immune Response to Two Admixtures of a Tetravalent Dengue Virus Vaccine

NCT01506570

Dengue viruses can cause dengue fever and other serious health conditions, primarily affecting people living in tropical regions of the world. This study will evaluate the safety and immune responses to two formulations of a tetravalent dengue virus vaccine in healthy adults who have previously been infected with a dengue virus or other flavivirus or have previously received a flavivirus vaccine.

Dengue

National Institute of Allergy and Infectious Diseases (NIAID)58 participantsStarted Dec 2011

Baltimore, Maryland, United States • Burlington, Vermont, United States • Burlington, Vermont, United States

Efficacy of Bevacizumab (Avastin) in Treatment of Acute NMO Exacerbations

Evaluating the Safety and Immune Response to Two Admixtures of a Tetravalent Dengue Virus Vaccine

Find Trials by Condition in Baltimore

Improving the Quality of Cardiopulmonary Resuscitation (CPR) During Pediatric Cardiac Arrest

Smoking Cessation for Veterans With Severe and Persistent Mental Illness

Familial Intracranial Aneurysm Study II

Study Evaluating the Pharmacokinetics of Keppra Extended Release (XR) in Children and Adults With Epilepsy

Metal Ion Release From an FDA-Approved Metal-on-Metal Total Hip Replacement Implant

Safety Study for the Treatment of Abdominal Aortic Aneurysms

TAXUS Libertē Post Approval Study

AIN457 Regimen Finding Study in Patients With Moderate to Severe Psoriasis

Effect of Azithromycin on Lung Function in 6-18 Year-olds With Cystic Fibrosis (CF) Not Infected With P. Aeruginosa

Efficacy and Safety of 4 Weeks of Treatment With Orally Inhaled BI1744/Tiotropium Bromide in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Combination of Orally Inhaled BI1744CL/Tiotropium Bromide in Patients With Chronic Obstructive Pulmonary Disease ( COPD)

An Open-Label Study to Evaluate Retreatment With LIPO-202

A Study of XL844 Administered as a Single Agent and in Combination With Gemcitabine in Adults With Advanced Malignancies

Safety Study of XL647 and XL147 Administered in Combination Daily in Adults With Solid Tumors

Complete Occlusion of Coilable Aneurysms

A Study to Evaluate the Safety and Efficacy of Adding Enfuvirtide to Oral Highly Active Antiretroviral Therapy (HAART) in Human Immunodeficiency Virus (HIV) Patients With Prior Treatment Experience

A Study of the Drug-Drug Interaction of RO5503781 and Posaconazole, the Relative Bioavailability of New Formulations of RO5503781 and the Food-Effect on the Pharmacokinetics of RO5503781 in Patients With Solid Tumors

Study of Phenoptin to Increase Phenylalanine Tolerance in Phenylketonuric Children on a Phenylalanine-restricted Diet