Clinical Trials in Baltimore

Showing 1221-1240 of 11,213 trials

A Study to Investigate HLA-G Targeted Exosome (SOB100) in Healthy Subjects

NCT07219940

The investigational drug, SOB100, is an HLA-G targeted exosome equipped with a nanobody namely anti-HLA-G VHH on the exosome membrane. This is a Phase I dose escalation study to exam the tolerability, safety, and pharmacokinetics in healthy subjects.

Healthy SubjectsExosomeTargeted Therapy

Shine-On Biomedical Co., Ltd.15 participantsStarted Dec 2025

Baltimore, Maryland, United States

COMPLETEDPhase 2< 1 mile

HKI-272 for HER2-Positive Breast Cancer and Brain Metastases

NCT01494662

The purpose of this research study is to determine how well neratinib works in treating breast cancer that has spread to the brain. Neratinib is a recently discovered oral drug that may stop breast cancer cells from growing abnormally by inhibiting (or blocking) members of a family of proteins that include Human Epidermal Growth Factor Receptor 2 (HER2). In this research study, the investigators are looking to see how well neratinib works to decrease the size of or stabilize breast cancer that has spread to the brain. The investigators are also looking at how previous treatments have affected your thinking (or cognition) and how much neratinib reaches the central nervous system.

Breast Cancer

Dana-Farber Cancer Institute140 participantsStarted Feb 2012

San Francisco, California, United States • Washington D.C., District of Columbia, United States • Baltimore, Maryland, United States +15 more locations

A Study to Investigate HLA-G Targeted Exosome (SOB100) in Healthy Subjects

HKI-272 for HER2-Positive Breast Cancer and Brain Metastases

Find Trials by Condition in Baltimore

Long-term Safety and Efficacy Study of MT-8554 in Postmenopausal Women With Vasomotor Symptoms

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVID-19 and Convalescence

Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

Cardamom and Topical Roseomonas in Atopic Dermatitis

Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease

Study to Evaluate Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-291 Moves Through the Body in Adult Participants With Non-Hodgkin's Lymphoma

Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA)

Phase 2a Evaluation of Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Patients With Primary Sclerosing Cholangitis (PSC)

Longitudinal Study for Central Nervous System Vasculitis

Open-label Trial Characterizing the PK of 3 SC Olanzapine Extended-release Formulations in Participants With Schizophrenia/Schizoaffective Disorder

Expanded Access Protocol: Umbilical Cord Blood Infusions for Children With Brain Injuries

Talimogene Laherparepvec and Panitumumab for the Treatment of Locally Advanced or Metastatic Squamous Cell Carcinoma of the Skin

Study of Gemcitabine, Cisplatin, AB680 and AB122 During First Line Treatment of Advanced Biliary Tract Cancers (QUIC)

A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments

Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors

Dose-Escalation Study of Oral Administration of LP-108 as Monotherapy and in Combination With Azacitidine in Patients With Relapsed or Refractory MDS, CMML, or AML

A Study of SHJ002 Sterile Ophthalmic Solution for Myopia Control