Clinical Trials in Baltimore

Showing 9461-9480 of 17,842 trials

H1N1v Virus Challenge Study in Healthy Subjects

NCT04044352

This is a study of a reverse-engineered, Good Manufacturing Practice (GMP) grade, antiviral-sensitive, influenza A/Bethesda/MM2/H1N1 virus (A/California/04/2009/H1N1-like) infection to assess the effect of pre-existing immunity on clinical and immunological responses. Up to 80 healthy adult subjects will undergo intranasal inoculation with A/Bethesda/MM2/H1N1 virus, and their clinical manifestations, viral shedding and immunological responses will be characterized. The Primary Objective for this study is to evaluate the association of symptomatic Reverse Transcription-Polymerase Chain Reaction (RT-PCR)-positive influenza virus infection post-challenge and pre-existing Hemagglutinin Inhibition Test (HAI) antibody titers.

Influenza

National Institute of Allergy and Infectious Diseases (NIAID)76 participantsStarted Oct 2019

Baltimore, Maryland, United States • St Louis, Missouri, United States • Durham, North Carolina, United States +1 more locations

COMPLETEDPhase 1< 1 mile

Intravaginal Artesunate for the Treatment of HPV+ High Grade Cervical Intraepithelial Neoplasia (CIN2/3)

NCT02354534

This phase I research protocol is designed to assess immunogenicity and clinical endpoints in patients with human papillomavirus (HPV) 16 cervical intraepithelial neoplasia (CIN)2/3. The protocol tests the use of artesunate in suppository formulation applied intravaginally in patients with cervical dysplasia (CIN2/3). The primary endpoint is to determine and evaluate the safety, tolerability, and feasibility of intravaginal administration of artesunate in health women with CIN2/3.

Cervical Intraepithelial Neoplasia Grade 2/3High-risk HPV (Any Strain)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins30 participantsStarted Feb 2015

Baltimore, Maryland, United States • Baltimore, Maryland, United States • Towson, Maryland, United States

H1N1v Virus Challenge Study in Healthy Subjects

Intravaginal Artesunate for the Treatment of HPV+ High Grade Cervical Intraepithelial Neoplasia (CIN2/3)

Find Trials by Condition in Baltimore

Corneal Collagen Cross-Linking for Ectasia (CXL)

Study Confirming A Human Challenge Model and Investigating The Safety Of VLA1701

Open Label, Phase II Study to Evaluate Efficacy and Safety of Oral Nilotinib in Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia (CML) Pediatric Patients.

Post Approval Study of the remedē System

Tack Optimized Balloon Angioplasty Study of the Tack Endovascular System™ in Femoropoliteal Arteries

Efficacy and Safety Study of Polidocanol Injectable Foam for the Treatment of Saphenofemoral Junction (SFJ) Incompetence

Safety and Efficacy of Corneal Collagen Cross-linking Following LASIK for Treatment of Hyperopia and Hyperopic Astigmatism

Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus

Melatonin and Salt on Blood Vessel Function

Internal Cues Versus External Cues for Eating and Activity

Safety Study of Varisolve® Procedure for Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt

A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study of SUN13834 in Adult Subjects With Atopic Dermatitis

Heart Sounds Registry

Building Community Capacity for Disability Prevention for Minority Elders (Positive Minds - Strong Bodies)

Evaluation of TRC101 in Subjects With Metabolic Acidosis Associated With Chronic Kidney Disease

Global Anticoagulant Registry in the Field

Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation Event

A Study Comparing MB02 and Avastin® in Subjects With Stage IIIB/IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC)