Clinical Trials in Baltimore

Showing 5881-5900 of 23,476 trials

A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma

NCT04139304

This feasibility trial studies how well daratumumab in combination with dose-adjusted etoposide, prednisone, vincristine sulfate, cyclophosphamide, and doxorubicin hydrochloride (DA-EPOCH) works in treating patients with newly diagnosed stage I-IV plasmablastic lymphoma. Plasmablastic lymphoma cells have high levels of a protein called CD38. Daratumumab is a monoclonal antibody that specifically targets CD38 expressing cells, and may help the body's immune system attack the cancer and interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as etoposide, prednisone, vincristine sulfate, cyclophosphamide, and doxorubicin hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving daratumumab may enhance the effectiveness of a standard chemotherapy (DA-EPOCH) in patients with plasmablastic lymphoma.

Plasmablastic LymphomaAnn Arbor Stage I Diffuse Large B-Cell LymphomaAnn Arbor Stage II Diffuse Large B-Cell Lymphoma+2 more

AIDS Malignancy Consortium15 participantsStarted May 2021

Miami, Florida, United States • Chicago, Illinois, United States • Baltimore, Maryland, United States +5 more locations

RECRUITINGNA< 1 mile

Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial

NCT05924477

Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial (DECLARE) is a multi-center, outcome-masked, randomized clinical trial. The purpose of this study is to compare glaucoma drainage device implantation in the anterior chamber (front part of the eye) and sulcus (small space between iris and front chamber of the eye) in efforts to minimize cell loss in the eye.

Glaucoma

University of Pennsylvania226 participantsStarted Jul 2023

San Francisco, California, United States • Walnut Creek, California, United States • Miami, Florida, United States +5 more locations

A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma

Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial

Find Trials by Condition in Baltimore

The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)

Adolescent Master Protocol for Participants 18 Years of Age or Older - Lite

A Study of NPX887 for Participants With Solid Tumors Known to Express B7-H7/HHLA2

Adolescent Master Protocol

Proliposomal Intravesical Paclitaxel for Treatment of Low-Grade, Stage Ta, Non Muscle Invasive Bladder Cancer

Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers

LTFU for All Cell and Gene Therapy Studies

A Nutritional Intervention in Police Officers

Intramyocardial Injection of Autologous UCB-MNC During Fontan Surgery for SRV Dependent CHD

Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma

BIG Study (Brain, Immune, and Gut Health Evaluation of Infants/Young Children Fed Infant Formula, and Later Supplemental Toddler Nutrition, With 5 Specific HMOs)

Gluten Technology and Education for Celiac Health

Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations

A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures

FS120 Phase 1/1b Study in Patients With Advanced Malignancies

A Phase 3b Study for the Treatment of Dystrophic Epidermolysis Bullosa (DEB) in New and Previously EB-101 Treated Patients

Cough Reduction in IPF With Nalbuphine ER

Benchmark Evidence Led by Latin America: Trial of Intracranial Pressure - Pediatrics