Ulcerative Colitis Clinical Trials

Showing 1001-1020 of 8,272 trials

A Clinical Trial of PR001 (LY3884961) in Patients With Peripheral Manifestations of Gaucher Disease (PROCEED)

NCT05487599

Study J3Z-MC-OJAE is a Phase 1/2, multicenter, open-label, dose-finding study of LY3884961 evaluating the safety and tolerability in adults with peripheral manifestations of GD. Up to 3 dose levels of LY3884961 will be assessed in 3 dose-finding cohorts of 3 patients. Following this, up to 6 patients may be enrolled in an expansion cohort. For each enrolled patient, the study will be approximately 5 years in duration, including up to a 60-day screening period. During the first 18 months after dosing, subjects will be evaluated for the effects of LY3884961 on safety, tolerability, immunogenicity, biomarkers, and efficacy. Patients will be followed for an additional 42 months to monitor safety, immunogenicity, and selected biomarker and efficacy parameters.

Gaucher DiseaseGaucher Disease, Type 1

Prevail Therapeutics15 participantsStarted Dec 2022

Chicago, Illinois, United States • Durham, North Carolina, United States • Fairfax, Virginia, United States +5 more locations

TERMINATEDNA

Combined Compared to Sequential Cognitive and Physical Training in Anterior Cruciate Ligament Reconstructed Individuals

NCT06845150

The goal of this clinical trial is to investigate changes in cognitive and physical performance after 10 weeks of dual or single task training in anterior cruciate ligament (ACL) reconstructed individuals. The main questions it aims to answer are: * Does cognitive performance in ACL reconstructed individuals change after multiple training sessions incorporating single versus dual-task? * Does physical performance and intrinsic motivation for training change over the course of 10 weeks when performing single versus dual-task training sessions? * What movement patterns do ACL reconstructed individuals show during a dual-task training in an immersive environment? Researchers will compare a combined dual-task training (combined physical and cognitive training) to a single task training (physical and cognitive training separately) to see if there are changes on cognitive performance depending on the training type. Participants will: * Perform dual-task or single task training twice per week for 10 weeks * Visit the clinic before and after the training period for tests * Visit the movement laboratory once for analysis of movement patterns

Anterior Cruciate Ligament Reconstruction Rehabilitation

Michelle C. Haas2 participantsStarted Jun 2025

Winterthur, Switzerland • Winterthur, Switzerland

A Clinical Trial of PR001 (LY3884961) in Patients With Peripheral Manifestations of Gaucher Disease (PROCEED)

Combined Compared to Sequential Cognitive and Physical Training in Anterior Cruciate Ligament Reconstructed Individuals

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