Ulcerative Colitis Clinical Trials

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PT003 MDI Cardiovascular Safety Study

NCT01349803

This study is primarily a safety study. The primary and secondary endpoints are based on 24-hour Holter monitor assessments obtained on Day 14 relative to baseline.

Chronic Obstructive Pulmonary Disease

Pearl Therapeutics, Inc.237 participantsStarted May 2011

Glendale, Arizona, United States • Fullerton, California, United States • Los Angeles, California, United States +17 more locations

COMPLETEDNA

The Effect of Continuous Positive Airway Pressure on Diastolic Function in Patients With Obstructive Sleep Apnea

NCT01854398

The association of obstructive sleep apnea (OSA) and cardiac diastolic dysfunction have been reported, and improvement of diastolic function after continuous positive airway pressure (CPAP) in OSA patients was observed. However, more detailed analysis of diastolic function by supine bicycle exercise echocardiography is lacking. The investigators hypothesized that 3 months of CPAP therapy in OSA patients will significantly improve diastolic functional parameters measured by exercise stress echocardiography. Patients with severe OSA (Apnea-hypopnea index \> 30) will be included in this study, and randomized to CPAP versus sham-CPAP group by 1:1 ratio. Supine bicycle exercise echocardiography, pulse wave velocity, 24 hours ambulatory blood pressure (BP), central BP will be checked before and after CPAP therapy and parameters will be compared.

Obstructive Sleep Apnea

Yonsei University60 participantsStarted May 2013

Seoul, Seoul, South Korea

PT003 MDI Cardiovascular Safety Study

The Effect of Continuous Positive Airway Pressure on Diastolic Function in Patients With Obstructive Sleep Apnea

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