Rheumatoid Arthritis Clinical Trials

Showing 3041-3060 of 25,423 trials

Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP

NCT05672030

The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant effector pathways that lead to clinical benefit.

Nasal PolypsAspirin-exacerbated Respiratory Disease

Brigham and Women's Hospital30 participantsStarted Oct 2022

Boston, Massachusetts, United States

Active Not RecruitingPhase 1

A Safety, Tolerability, and Immunogenicity Study of mRNA-1345 and mRNA-1365 in Participants Aged 5 Months to <24 Months

NCT05743881

The purpose of this study is to assess the safety and immunogenicity of mRNA-1365, an mRNA vaccine targeting respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) and mRNA-1345, an mRNA vaccine targeting RSV, in participants aged 5 months to \<24 months.

Respiratory Syncytial VirusHuman Metapneumovirus

ModernaTX, Inc.186 participantsStarted Feb 2023

Los Angeles, California, United States • Los Angeles, California, United States • Englewood, Colorado, United States +47 more locations

Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP

A Safety, Tolerability, and Immunogenicity Study of mRNA-1345 and mRNA-1365 in Participants Aged 5 Months to <24 Months

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