Rheumatoid Arthritis Clinical Trials

Showing 20541-20560 of 47,334 trials

Pharmacokinetic Interaction Between Nitazoxanide and Atazanavir/Ritonavir in Healthy Volunteers

NCT05680792

The goal of this study is to 1. determine the most effective biological sampling method that best describe the pharmacokinetics nitazoxanide/tizoxanide and to; 2. evaluate the clinical significance of the pharmacokinetics interaction between nitazoxanide (1000mg twice daily) and atazanavir/ritonavir (300mg/100mg). Participants will be given 1000mg oral nitazoxanide taken twice daily for seven days. After a washout period of three weeks, they will receive 1000mg oral nitazoxanide with atazanavir/ritonavir (taken orally at 300/100 mg). Five millimetres of whole blood or swab or saliva samples will be collected from them at 0.5, 1, 2, 4, 6, 8 and 12 hours after dose on day 1, 5 and 7. The pharmacokinetic of nitazoxanide when administered alone and alongside atazanavir/ritonavir will be compared to see if concomitant administration of nitazoxanide and atazanavir/ritonavir affect nitazoxanide pharmacokinetics

Drug Interaction

Obafemi Awolowo University17 participantsStarted Sep 2020

Ile-Ife, Osun State, Nigeria

UNKNOWNPhase 3

Efficacy, Safety, pharmacokinetiсs, Immunogenicity of GNR-067 and Lucentis®

NCT04667039

This is a randomized, double-blind, comparative, parallel group study of the efficacy, safety pharmacokinetics, and immunogenicity of GNR-067 and Lucentis® in patients with neovascular (wet) age-related macular degeneration.

Age Related Macular Degeneration (ARMD)

AO GENERIUM408 participantsStarted Mar 2022

Ivanovo, Ivanovo Oblast, Russia • Saint Petersburg, Leningradskaya Oblast', Russia • Moscow, Moscow Oblast, Russia +6 more locations

Pharmacokinetic Interaction Between Nitazoxanide and Atazanavir/Ritonavir in Healthy Volunteers

Efficacy, Safety, pharmacokinetiсs, Immunogenicity of GNR-067 and Lucentis®

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