Sodium Lactate and Brain Relaxation (LSD)

Exclusion Criteria

• •Emergency surgery
• •Age \< 18 years old or \> 75 years old
• •ASA score IV-V
• •Legal incapability or limited legal capacity
• •Patient who will unlikely cooperate to the study and/or poor cooperation foreseen by the investigator
• •Preoperative Glasgow score \< 13
• •Pregnant woman and/or breastfeeding
• •Body index masse\< 18 kg.m-2 ou \> 30 kg.m-2
• •Preoperative hyponatremia \< 130mmol/l or hypernatremia \> 145 mmol/l
• •Osmotherapy in the 24 hours prior to the surgery (Mannitol, Hypertonic saline, Sodium lactate)
• •Congestive heart failure
• •Moderate ou severe chronic kidney disease, defined by a creatinine clearance (MDRD) \< 60 ml/min
• •End-stage liver disease (Child Pugh ≥ B7)
• •Myasthenia gravis
• •External ventricular drain or ventriculoperitoneal shunt of cerebrospinal fluid
• •Allergy to Mannitol 20% or one of his excipients
• •Allergy to Sodium Lactate or one of his excipients
• •Contraindication for propofol
• •Allergy to anesthetic agents (propofol, remifentanil, cisatracurium)
• •Refusal of consent
• •Patient within the exclusion period of another study or planned by the "national file of volunteers"
• •Medical history of cognitive disorders or demencia