Rheumatoid Arthritis Clinical Trials in Philadelphia

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Reconstructing Consciousness and Cognition

NCT01911195

Currently it is unknown how the human brain reorganizes its network organization to generate conscious experience and cognitive activity after a period of unconsciousness. Therefore, the purpose of this study is to assess how cognitive activity is reconstructed after general anesthesia. The investigators hypothesize that the brain's transition from unconsciousness to consciousness and full cognition is a complex process that occurs over an extended period of time. Specifically, the investigators hypothesize the following order of cognitive reconstitution: responsiveness to command, attention, complex scanning and visual tracking, working memory, and executive function. Volunteers will be healthy participants who are anesthetized with commonly used anesthetic drugs as well as a non-anesthetized group to control for circadian influences. A total of 60 subjects will be recruited for this study. All subjects (male and female) will perform basic tests for cognition on a laptop computer at 30-minute intervals during this study. The testing battery to be administered was assembled to assess multiple cognitive functions in order to determine whether and how cognitive processes return to baseline function. Electroencephalogram (measuring brain electrical activity) data will be monitored and recorded during both anesthesia and cognitive testing, for subsequent analysis. This study is significant because it could lead to a better understanding of the neural correlates of human consciousness, as well as normal and abnormal conscious state transitions (including barriers to such transitions).

Postoperative Cognitive Dysfunction

University of Michigan60 participantsStarted Jul 2013

Ann Arbor, Michigan, United States • St Louis, Missouri, United States • Philadelphia, Pennsylvania, United States

COMPLETEDEARLY Phase 1< 1 mile

Procalcitonin to Reduce Antibiotic Use in Pediatric Pneumonia

NCT04963764

This pilot study will evaluate study processes and feasibility of a future large-scale clinical trial that proposes to test whether low-risk children managed as outpatients with community-acquired pneumonia (CAP) and procalcitonin (PCT) levels \<0.25 ng/mL treated with placebo have a similar clinical response to those treated with antibiotics and fewer adverse effects.

PneumoniaPediatric Respiratory DiseasesAntibiotic Use+1 more

Ann & Robert H Lurie Children's Hospital of Chicago5 participantsStarted Oct 2021

Chicago, Illinois, United States • Cincinnati, Ohio, United States • Philadelphia, Pennsylvania, United States

Reconstructing Consciousness and Cognition

Procalcitonin to Reduce Antibiotic Use in Pediatric Pneumonia

Rheumatoid Arthritis Trials in Other Cities

CPI-613 and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma

Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

A Pharmacokinetics Study of MK-7655A in Pediatric Participants With Gram-negative Infections (MK-7655A-020)

PET-CT in Determining the Radioembolization Dose Delivered to Patients With Liver Metastasis, Primary Liver Cancer, or Biliary Cancer

The INSPIRE Study: Probable Benefit of the Neuro-Spinal Scaffold for Treatment of AIS A Thoracic Acute Spinal Cord Injury

Efficacy Evaluation of VERU-111 for mCRPC in Patients Who Have Failed at Least One Androgen Receptor Targeting Agent

Evaluation of Dupilumab in Patients With Atopic Keratoconjunctivitis (AKC)

Open-label Long-Term Safety and Efficacy of SPN-812 (Viloxazine Extended-release Capsule) in Adults With ADHD

ILLUMENATE Pivotal Post-Approval Study (PAS)

Afimoxifene in Reducing the Risk of Breast Cancer in Women With Mammographically Dense Breast

A Prospective, Global, Multi-center, Treatment Registry Study of Intravenous Immunoglobulin Maintenance Therapy in Alloantibody Positive Renal Allograft Recipients

Encorafenib, Binimetinib and Cetuximab in Subjects With Previously Untreated BRAF-mutant ColoRectal Cancer

Ascertaining the Radiologic Prognostic Importance of Extranodal Extension on Imaging (iENE) in Head and Neck Cancer

Alleviation of Common Cold Symptoms

COMbination of Bipolar Androgen Therapy and Nivolumab

Evaluation of Real-World Data on the Performance of the TECNIS Odyssey™ IOL

Utility of Transdermal Optical Imaging (TOI) as a Non-invasive Measure of Hydration Status: Phase 3a for Model Development

Double-Blinded, Placebo-Controlled Phase 1b Study for Safety, PK, Efficacy, PD of RO7049665 in Participants With Ulcerative Colitis (UC)

Other Conditions in Philadelphia