Rheumatoid Arthritis Clinical Trials in Philadelphia

Showing 1301-1320 of 3,347 trials

A Study to Assess the Safety and Efficacy of ASP1650, a Monoclonal Antibody Targeting Claudin 6 (CLDN6), in Male Subjects With Incurable Platinum Refractory Germ Cell Tumors

NCT03760081

The purpose of this study was to establish the recommended phase 2 dose (RP2D) of ASP1650 (Safety Lead-in Phase), as well as, evaluate the efficacy of ASP1650 as measured by confirmed objective response rate (ORR) (phase 2) in participants with incurable platinum refractory germ cell tumors. This study also evaluated the following efficacy measures for confirmed objective response rate (ORR); clinical benefit rate (CBR); duration of response (DOR); and progression-free survival (PFS); as well as safety and tolerability; the effect of ASP1650 on changes in serum beta human chorionic gonadotropin (βhCG) and alpha-fetoprotein (AFP); and the pharmacokinetics of ASP1650.

Incurable Platinum Refractory Germ Cell TumorsTumors

Astellas Pharma Global Development, Inc.19 participantsStarted Mar 2019

Indianapolis, Indiana, United States • New York, New York, United States • Philadelphia, Pennsylvania, United States

Active Not RecruitingNA< 1 mile

Memory Retrieval and Encoding Investigated by Neural Stimulation

NCT04286776

The purpose of this research is to understand biomarkers of human memory through correlational analyses and to use focal electrical stimulation as a causal manipulation to understand how biomarkers of memory relate to other brain states and behavioral measures.

Epilepsy Intractable

University of Pennsylvania800 participantsStarted Oct 2014

Aurora, Colorado, United States • Atlanta, Georgia, United States • Bethesda, Maryland, United States +8 more locations

A Study to Assess the Safety and Efficacy of ASP1650, a Monoclonal Antibody Targeting Claudin 6 (CLDN6), in Male Subjects With Incurable Platinum Refractory Germ Cell Tumors

Memory Retrieval and Encoding Investigated by Neural Stimulation

Rheumatoid Arthritis Trials in Other Cities

Preemie Hypothermia for Neonatal Encephalopathy

Entyvio (Vedolizumab) Long Term Safety Study

Long Term Follow Up of Sub-retinal Transplantation of hESC Derived RPE Cells in Patients With AMD

GTSCOPE - To Evaluate the Natural Progression of Dry Age-related Macular Degeneration (AMD)

A Study to Test Whether Taking BI 1358894 for 8 Weeks Helps Adults With Post-traumatic Stress Disorder

A Phase 3 Safety and Efficacy Study of Fovista® (E10030) Intravitreous Administration in Combination With Lucentis® Compared to Lucentis® Monotherapy

Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

Study to Investigate LP352 in Subjects With Developmental and Epileptic Encephalopathies

Study to Evaluate the Safety, Tolerability,Pharmacokinetics, and Antitumor Activity of a Thorium-227 Labeled Antibody-chelator Conjugate Alone and in Combination With Darolutamide, in Patients With Metastatic Castration Resistant Prostate Cancer

A Study to Assess the Long Term Effect, Safety and Metabolism of a Solifenacin Liquid Suspension in Participants 5 to 18 Years of Age With Neurogenic Detrusor Overactivity

Clareon Toric vs Eyhance Toric

A Dose Escalation and Expansion Study of ASP4132 to Subjects With Advanced Refractory Tumors and Lymphoma

Efficacy, Safety, Tolerability, and Biomarkers of Ibudilast (MN-166) in Patients Hospitalized With COVID-19 at Risk for ARDS

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ASP5094 Following Multiple Intravenous Doses in Subjects With Rheumatoid Arthritis on Methotrexate

A Study to Investigate How Effective and Safe Solifenacin Succinate Suspension is in Treating Children/Adolescents Aged 5 to Less Than 18 Years With Symptoms of Overactive Bladder (OAB) Compared to a Non-active Drug

North American Prodromal Synucleinopathy Consortium

Effect of Celecoxib on Postoperative Analgesia and Disease Severity in AERD Patients with CRS

Stratification of Risks of Conversion of Radiologically Isolated Syndromes (RIS) by Identifying Biomarkers in Serum and Cerebrospinal Fluid.

Other Conditions in Philadelphia