Rheumatoid Arthritis Clinical Trials in Philadelphia

Showing 941-960 of 1,834 trials

(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies

NCT02561988

This is a Phase 1, open-label, dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antineoplastic activity of avapritinib (also known as BLU-285), administered orally (PO), in adult patients with advanced systemic mastocytosis and other relapsed or refractory myeloid malignancies. The study consists of 2 parts:, dose-escalation (Part 1) and expansion (Part 2).

Aggressive Systemic MastocytosisSystemic Mastocytosis-associated Hematologic Non-mast Cell DiseaseMast Cell Leukemia+1 more

Blueprint Medicines Corporation86 participantsStarted Mar 2016

Stanford, California, United States • Denver, Colorado, United States • Atlanta, Georgia, United States +8 more locations

COMPLETEDPHASE3< 1 mile

Neoadjuvant Carboplatin and Vincristine and Standard Local Ophthalmic Therapy in Treating Patients With Intraocular Retinoblastoma

NCT00079417

This phase III trial is studying how well giving carboplatin and vincristine together with standard local ophthalmic therapy works in treating children with intraocular retinoblastoma. Drugs used in chemotherapy, such as carboplatin and vincristine, work in different ways to stop tumor from dividing so they stop growing or die. It is not yet known whether neoadjuvant chemotherapy combined with standard local ophthalmic therapy is effective in treating intraocular retinoblastoma.

Intraocular Retinoblastoma

Children's Oncology Group28 participantsStarted Dec 2005

Los Angeles, California, United States • Chicago, Illinois, United States • Boston, Massachusetts, United States +7 more locations

(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies

Neoadjuvant Carboplatin and Vincristine and Standard Local Ophthalmic Therapy in Treating Patients With Intraocular Retinoblastoma

Rheumatoid Arthritis Trials in Other Cities

Dose Ranging Study of Rimegepant (BMS-927711) for the Acute Treatment of Migraine

Expanded Access Protocol Using 131I-MIBG

MORE-PC: A 30-day Automated SMS Program to Support Post-discharge Transitions of Care

Study of the Safety and Efficacy of OPC-34712 as a Complementary Therapy in the Treatment of Adult Attention Deficit/Hyperactivity Disorder

Thoracolumbar Burst Fractures Study Comparing Surgical Versus Non-surgical Treatment

Autologous or Donor Stem Cell Transplantation in Treating Patients With Recurrent Non-Hodgkin's Lymphoma (BMT CTN 0202)

Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma

Inhaled ZYESAMI™ (Aviptadil Acetate) for the Treatment of Severe COVID-19

Assessment of Safety and Efficacy of Nerivio for the Migraine Prevention

Pembrolizumab, Belantamab and Dexamethasone in Refractory Multiple Myeloma.

Efficacy, Tolerability, and Safety of DFN-15

Effects of Oral Levosimendan on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis (ALS): Open-Label Extension

Ipilimumab and/or Nivolumab in Combination With Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

Safety and Efficacy in Adult Subjects With Acute Migraines

A Study of ALRN-6924 for Protection of Chemotherapy-Induced Side Effects in Patients With TP53-Mutant Breast Cancer

Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity

Study of the Safety and Efficacy of APX3330 in Diabetic Retinopathy

Microarray Expression Profiling to Identify Stereotypic mRNA Profiles in Human Parturition

Other Conditions in Philadelphia