Rheumatoid Arthritis Clinical Trials in New York

Showing 1241-1260 of 3,596 trials

Administration of Hydroxychloroquine (Plaquenil) to African Americans and Hispanics for the Treatment of Mild to Severe Ulcerative Colitis

NCT05119140

The objective of this study is to assess the efficacy of hydroxychloroquine (HCQ) when combined with Mesalamine in reducing clinical and histologic disease activity in patients who have active mild to severe Ulcerative Colitis (UC) and also to assess the immunological effects of hydroxychloroquine in this population. These outcomes will be evaluated both clinically and experimentally. In vitro, flow cytometry will be employed to measure the expression of CTLA-4 on activated CD4+CD25+CD127- Tregs from patients prior to treatment with HCQ, and then at the end of a 4 month follow up period. Suppression assays will be used to determine the functional capacity of the patient derived Tregs. Clinically, patients will be monitored for remission as defined by reduction in patient reported stool frequency and rectal bleeding (mayo sub-score 0 or 1) and endoscopically, by improvement in mucosal appearance (mayo sub-score 0 or 1), all objective measures in the mayo score.

Ulcerative Colitis (Disorder)

Icahn School of Medicine at Mount Sinai3 participantsStarted Jun 2022

Atlanta, Georgia, United States • New York, New York, United States

TERMINATEDPhase 1< 1 mile

(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations

NCT05241873

This is a Phase 1/2, open-label first-in-human study of the safety, pharmacokinetics (PK), pharmacodynamics, and anti-tumor activity of BLU-451 monotherapy and BLU-451 in combination with platinum-based chemotherapy (carboplatin and pemetrexed). All participants will receive BLU-451 on a 21-day treatment cycle.

Lung Neoplasm MalignantCarcinoma, Non-Small-Cell LungRespiratory Tract Neoplasms+17 more

Blueprint Medicines Corporation103 participantsStarted Mar 2022

Duarte, California, United States • Los Angeles, California, United States • Aurora, Colorado, United States +20 more locations

Administration of Hydroxychloroquine (Plaquenil) to African Americans and Hispanics for the Treatment of Mild to Severe Ulcerative Colitis

(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations

Rheumatoid Arthritis Trials in Other Cities

A Follow up Study of Patients Treated With Imlifidase Prior to Kidney Transplantation

Framing Eighteen Coils in Cerebral Aneurysms Trial

Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)

The ShortCut™ Study Protocol

Virtual Reality Distraction During Outpatient Pediatric Orthopedic Procedures

Filgotinib in Long-Term Extension Study of Adults With Ulcerative Colitis

Speech and Arm Combined Exergame

A Study of Acute Respiratory Infections in Global Outpatient Setting

Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)

A Phase 2b Study of BNC210 Tablet Formulation in Adults With Post-Traumatic Stress Disorder (PTSD)

Is Methenamine Prophylaxis for Urinary Tract Infection After Midurethral Sling as Effective as Antibiotic Prophylaxis?

Evaluation of Donated Human Embryos Following in Vitro Fertilization

Study to Evaluate the Safety of CG-P5 Peptide Eye Drops in Patients Diagnosed With Age-related Wet Macular Degeneration

Safety and Immunogenicity of CodaVax-RSV in Seropositive and Seronegative Children

A Study on the Immune Response and Safety of an Adjuvanted Human Papillomavirus Vaccine When Given to Healthy Women 16 to 26 Years of Age

Futibatinib Versus Gemcitabine-Cisplatin Chemotherapy as First-Line Treatment of Patients With Advanced Cholangiocarcinoma Harboring FGFR2 Gene Rearrangements

Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors

A Two-Part Infant Study for Early Diagnosis of Respiratory Syncytial Virus (RSV) and Evaluation of JNJ-53718678 in RSV Acute Respiratory Tract Disease

Other Conditions in New York