Rheumatoid Arthritis Clinical Trials in New York

Showing 3421-3440 of 3,596 trials

A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS

NCT00000674

To collect information on the effectiveness and toxicity of clindamycin plus pyrimethamine and leucovorin calcium for the treatment of acute toxoplasmic encephalitis in adult patients with AIDS. Toxoplasmic encephalitis (encephalitis caused by Toxoplasma gondii) is the most frequent cause of focal central nervous system infection in patients with AIDS. If untreated, the encephalitis is fatal. At present, it is standard practice to give a combination of pyrimethamine and sulfadiazine to treat toxoplasmic encephalitis. The high frequency of sulfonamide-induced toxicity in AIDS patients often makes completion of a full course of therapy difficult. There is some information that high doses of parenteral (such as by injection) clindamycin used with pyrimethamine may be as effective as pyrimethamine plus sulfadiazine in the management of the acute phase of toxoplasmic encephalitis in patients with AIDS. Administration of parenteral clindamycin for prolonged periods of time, however, is costly, requires hospitalization, and is inconvenient for the patient. There is some indication that treatment of AIDS patients with acute toxoplasmic encephalitis with oral clindamycin may be effective. Leucovorin calcium is useful in preventing pyrimethamine-associated bone marrow toxicity.

Toxoplasmosis, CerebralHIV Infections

National Institute of Allergy and Infectious Diseases (NIAID)30 participants

Los Angeles, California, United States • Palo Alto, California, United States • San Diego, California, United States +10 more locations

COMPLETEDPhase 1< 1 mile

DX-8951f in Treating Children With Advanced Solid Tumors or Lymphomas

NCT00004212

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of DX-8951f in treating children who have advanced solid tumors or lymphomas that have not responded to previous therapy.

Brain and Central Nervous System TumorsLymphomaUnspecified Childhood Solid Tumor, Protocol Specific

Daiichi SankyoStarted Sep 1999

New York, New York, United States • Memphis, Tennessee, United States • Dallas, Texas, United States +1 more locations

A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS

DX-8951f in Treating Children With Advanced Solid Tumors or Lymphomas

Rheumatoid Arthritis Trials in Other Cities

Effect of Intravitreal Ranibizumab on Radiation Retinopathy Following Plaque Brachytherapy for Choroidal Melanoma

Efficacy of Ramelteon on Transient Insomnia in Healthy Adults

Study of Abatacept (BMS-188667) in Subjects With Active Rheumatoid Arthritis on Background Non-biologic DMARDS (Disease Modifying Antirheumatic Drugs) Who Have an Inadequate Response to Anti-TNF Therapy

Study of Levalbuterol and Racemic Albuterol in Pediatric Subjects With Reactive Airways Disease (RAD)

A Multicenter, Double-Blind Study to Investigate the Safety and Efficacy of Arimoclomol in Volunteers With ALS

Putting Electroencephalography (EEG) in the Emergency Department

Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis

Study to Assess Efficacy of Tacrolimus + Methotrexate Versus Placebo + Methotrexate in Treatment of Rheumatoid Arthritis

NINDS CRC Chronic Migraine Treatment Trial

FACTS II: A Study to Test the Safety and Effectiveness of a New Medication on the Treatment of Active Ulcerative Colitis

Study of Urgent PC Versus Sham Effectiveness in Treatment of Overactive Bladder Symptoms

Medial Versus Traditional Approach to US-guided TAP Blocks for Open Inguinal Hernia Repair

Heat Versus Ice in the Acute Management of Neck and Back Strain Injuries

Suramin Plus Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Evaluating the Ability of Zoledronic Acid to Reduce the Rate of Subsequent Osteoporotic Fractures After a Hip Fracture

Study Evaluating the Effect of Sirolimus on Non-Melanoma Skin Cancer in Kidney Transplant Recipients

A Multicenter, Dose Ranging Safety and Pharmacokinetics Study of Arimoclomol in ALS

DElivery of Self Training and Education for Stressful Situations-Primary Care Version

Other Conditions in New York