Rheumatoid Arthritis Clinical Trials in Chicago

Showing 2801-2820 of 3,890 trials

Ruxolitinib Prior to Transplant in Patients With Myelofibrosis

NCT01790295

The purpose of this study is to find out if giving the study drug Ruxolitinib (INC424) prior to a combination of other chemotherapeutic drugs (Fludarabine and Busulfan) before infusing another person's hematopoietic stem cells (bone marrow transplantation) will be successful in people who have advanced primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF) or post-essential thrombocythemia myelofibrosis (PET-MF), collectively known as myelofibrosis (MF). MF is a disorder in which bone marrow tissue develops in abnormal sites because the bone marrow itself undergoes fibrosis or scarring. This study plans to evaluate whether adding the drug Ruxolitinib will further aid in reducing pre-transplant spleen size, improve physical performance levels and reduce adverse events (side effects) related to the transplant. Ruxolitinib is a drug that is approved by the FDA for the treatment of patients with advanced forms of myelofibrosis. Using Ruxolitinib prior to stem cell transplantation is experimental.

Primary MyelofibrosisPost Polycythemia Vera MyelofibrosisPost Essential Thrombocythemia Myelofibrosis

John Mascarenhas21 participantsStarted Nov 2013

Atlanta, Georgia, United States • Chicago, Illinois, United States • Westwood, Kansas, United States +5 more locations

COMPLETEDPhase 32.2 miles

Efficacy, Safety, and Tolerability of Oral Ubrogepant in the Acute Treatment of Migraine

NCT02867709

This study will evaluate the efficacy, safety, and tolerability of 2 doses of ubrogepant (25 and 50 mg) compared to placebo for the acute treatment of a single migraine attack.

Migraine, With or Without Aura

Allergan1,686 participantsStarted Aug 2016

Birmingham, Alabama, United States • Chandler, Arizona, United States • Phoenix, Arizona, United States +106 more locations

Ruxolitinib Prior to Transplant in Patients With Myelofibrosis

Efficacy, Safety, and Tolerability of Oral Ubrogepant in the Acute Treatment of Migraine

Rheumatoid Arthritis Trials in Other Cities

Study of Itacitinib in Combination With Corticosteroids for the Treatment of Acute GVHD

Project LIFT - Promoting Healthy Behavior Through a Wearable Fitness Device and Financial Incentives

Veterans Individual Placement and Support Towards Advancing Recovery

Model 4965 Post-Approval Study

Investigational Device Exemption Study to Determine the Safety and Efficacy of the Astron and Pulsar Stents

A Dose Range Finding Study of JNJ-38518168 in Patients With Active Rheumatoid Arthritis in Spite of Treatment With Methotrexate

Rate Control Versus Rhythm Control For Postoperative Atrial Fibrillation

Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage

Whole-Body Cooling for Birth Asphyxia in Term Infants

A Study Exploring the Safety, Tolerability, and Efficacy of a 28 Day Course Followed by an Additional 56 Day Course of Itacitinib in Subjects With Active Rheumatoid Arthritis

Study to Assess Duration of Indwelling Catheter After Sacrocolpopexy

CRT Implant Strategy Using the Longest Electrical Delay for Non-left Bundle Branch Block Patients

Tetra-O-Methyl Nordihydroguaiaretic Acid in Treating Patients With Recurrent High-Grade Glioma

Validation of the Itch Reported Outcome (ItchRO) Diaries in Pediatric Cholestatic Liver Disease

Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation

Inflammation and the Host Response to Injury (Trauma)

Validation of Non-Invasive Intracranial Pressure (ICP) Monitoring Device

An Efficacy and Safety Study of Ustekinumab in Participants With Active Nonradiographic Axial Spondyloarthritis

Other Conditions in Chicago