Inflammation and the Host Response to Injury (Trauma)

Exclusion Criteria

• •Age \< 16
• •Anticipated survival of \<24 hours from injury
• •Anticipated survival \<28 days due to pre-existing medical condition
• •Inability to obtain first blood draw within first 12 hours after injury
• •Traumatic brain injury; i.e., GCS ≤8 after ICU admission AND brain computerized tomography scan abnormality within 12 hours after injury
• •Inability to obtain informed consent
• •Pre-existing, ongoing immunosuppression - e.g. transplant recipient
• •Pre-existing, ongoing immunosuppression - e.g. chronic high dose corticosteroids (\>20 mg/prednisone-equivalents/day)
• •Pre-existing, ongoing immunosuppression - e.g. oncolytic drug(s) therapy within the past 14 days
• •Pre-existing, ongoing immunosuppression - e.g. HIV positive AND CD4 count \<200 cells/mm3
• •Possible requirement for early immunosuppression - e.g. significant likelihood of requiring high dose corticosteroids (e.g. spinal injury)
• •Significant pre-existing organ dysfunction - lung: currently receiving home oxygen therapy, as documented in medical records
• •Significant pre-existing organ dysfunction - heart: congestive heart failure, as documented in medical records
• •Significant pre-existing organ dysfunction - renal: chronic renal failure (creatinine \>2)
• •Significant pre-existing organ dysfunction - liver: cirrhosis with portal hypertension or encephalopathy
• •Patient injured while sampling enrollment temporarily on hold