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Rheumatoid Arthritis Clinical Trials in Chicago | 3,890 Studies | Clareo Health

Clinical Trials Rheumatoid ArthritisChicago

Rheumatoid Arthritis Clinical Trials in Chicago

Find 3,890 clinical trials for rheumatoid arthritis near Chicago, Illinois. Connect with research centers in your area.

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Showing 2101-2120 of 3,890 trials

COMPLETEDPhase 42.2 miles

Efficacy of Erenumab on Functional Impact of Migraine

NCT04465357

The purpose of this study is to assess the efficacy of erenumab on functional impact due to Migraine in adults.

Merle Diamond55 participantsStarted Oct 2020

Chicago, Illinois, United States • City of Saint Peters, Missouri, United States • Springfield, Missouri, United States

COMPLETEDPhase 32.2 miles

Antiepileptic Efficacy Study of GWP42003-P in Children and Young Adults With Dravet Syndrome (GWPCARE1)

NCT02091375

To investigate the potential antiepileptic effects of cannabidiol (GWP42003-P) in children and young adults with Dravet syndrome.

EpilepsyDravet Syndrome

Jazz Pharmaceuticals120 participantsStarted Mar 2015

Miami, Florida, United States • Orlando, Florida, United States • Atlanta, Georgia, United States +19 more locations

Rheumatoid Arthritis Trials in Other Cities

New York Los Angeles Houston Phoenix Philadelphia San Antonio

Data from ClinicalTrials.govTerms

TERMINATEDPhase 42.2 miles

US Guided GNB vs Saline Injection for TKA

NCT03316118

Do ultrasound-guided genicular nerve blocks with 0.5% bupivacaine provide improved knee analgesia for patients recovering from total knee replacement surgery compared to saline injection? Hypotheses: The investigators hypothesize that the combination of ultrasound-guided adductor canal block (ACB) and genicular nerve block will achieve lower opioid consumption and therefore lead to decreased systemic side effects and improved overall satisfaction compared to ultrasound-guided saline injection for patients undergoing minimally invasive elective total knee arthroplasty (TKA).

Postoperative PainTotal Knee ArthroplastyNerve Block

Northwestern University2 participantsStarted Oct 2017

Chicago, Illinois, United States

COMPLETEDNA2.2 miles

The Impact of High-Flow Nasal Cannula on Swallow Function

NCT03590457

Background: High-flow nasal cannula (HFNC) is a non-invasive heated and humidified oxygen delivery device that is capable of delivering high-flow rates. It is a relatively new modality that has been introduced as an alternative to conventional oxygen therapy. The clinical value of the use of HFNC is not limited to its ventilation and oxygenation effects, it enables the patient to talk and is purported to permit oral feeding during oxygen therapy despite the limited evidence regarding its impact on swallow function. This study will determine the impact of different flow rates of a high-flow nasal cannula on spontaneous swallowing frequency at rest and swallowing effort and timing while swallowing. Methods: This is a prospective study designed to measure swallowing frequency and swallowing effort in fifty healthy adult volunteers. Participants will receive three levels of HFNC flow rates (30, 45, and 60 L/min) through nasal prongs. The study participants will be asked to swallow measured amounts of water and applesauce and subjected to each flow rate for 15 minutes. Swallowing effort measurement through surface electromyography (sEMG) will be recorded at baseline and the three levels of HFNC flow rates interventions.

Swallowing DisorderRespiratory Insufficiency

Rush University Medical Center18 participantsStarted Jun 2018

Chicago, Illinois, United States

WITHDRAWNNA2.2 miles

Low-moderate Intensity Pedaling During Immunotherapy Administration

NCT04127318

The purpose of this study is to determine the feasibility pedaling using an under-the desk bike during immunotherapy infusions. Also, the study hopes to evaluate how pedaling impacts quality of life and treatment response biomarkers. Lastly, the study will evaluate the relationships between treatment response and muscle mass which is evaluated with computerized tomography (CT) scans.

Cancer of SkinCancer of KidneyCancer of Bladder+2 more

Rush University Medical CenterStarted Jan 2020

Chicago, Illinois, United States

COMPLETEDPhase 22.2 miles

An Efficacy Study of MORAb-009 (Amatuximab) in Subjects With Pleural Mesothelioma

NCT00738582

This research is being done to find out if pemetrexed and cisplatin work better when given together with an experimental drug called MORAb-009 in patients with malignant pleural mesothelioma.

Malignant Pleural Mesothelioma

Morphotek89 participantsStarted Dec 2008

Birmingham, Alabama, United States • La Jolla, California, United States • Los Angeles, California, United States +25 more locations

TERMINATEDPhase 32.2 miles

A Study of Cobimetinib Plus Atezolizumab Versus Pembrolizumab in Participants With Previously Untreated Advanced BRAFv600 Wild-Type Melanoma

NCT03273153

This is a Phase III, multicenter, open-label, randomized study designed to evaluate the efficacy, safety, and pharmacokinetics of cobimetinib plus atezolizumab compared with pembrolizumab in treatment-naive participants with advanced BRAFV600 wild-type melanoma.

Advanced BRAFV600 Wild-type Melanoma

Hoffmann-La Roche446 participantsStarted Dec 2017

Tucson, Arizona, United States • Duarte, California, United States • Los Angeles, California, United States +118 more locations

COMPLETEDPhase 32.2 miles

Effects of Pneumatic Vitreolysis on Vitreomacular Traction

NCT03647267

Eyes with idiopathic symptomatic vitreomacular traction (VMT) without a macular hole will be randomly assigned to 0.3-mL intraocular gas (C3F8) injection or sham injection to determine if pneumatic vitreolysis (PVL) is effective in releasing VMT.

Vitreomacular Traction

Jaeb Center for Health Research46 participantsStarted Oct 2018

Campbell, California, United States • Huntington Beach, California, United States • Mountain View, California, United States +38 more locations

COMPLETEDPhase 32.2 miles

Corticosteroid Lumbar Epidural Analgesia for Radiculopathy

NCT03372161

This is a research study of SP-102, an experimental medication designed to relieve pain in patients with a specific type of leg pain. The medication is given once by your healthcare professional, with a possibility of a second injection as early as about 1 month after the first treatment. The purpose of the study is to measure how well a single injection of the experimental medication, SP-102, relieves pain. The study will also investigate the side effects of SP-102.

Lumbosacral Radicular Pain

Scilex Pharmaceuticals, Inc.401 participantsStarted Dec 2017

Mobile, Alabama, United States • Phoenix, Arizona, United States • Tempe, Arizona, United States +34 more locations

COMPLETEDPhase 1/22.2 miles

A Study of Telaglenastat (CB-839) in Combination With Palbociclib in Patients With Solid Tumors

NCT03965845

This is a Phase 1b/2 study to determine the recommended phase 2 dose (RP2D), safety and tolerability, pharmacokinetics (PK) and clinical activity of the glutaminase inhibitor telaglenestat (CB-839) with the CDK4/6 Inhibitor, palbociclib in participants with advanced/metastatic solid tumors.

Solid TumorsNSCLCCRC+1 more

Calithera Biosciences, Inc53 participantsStarted Jun 2019

Santa Monica, California, United States • Atlanta, Georgia, United States • Chicago, Illinois, United States +7 more locations

TERMINATEDPhase 28.0 miles

A Multiple Dose Study of Repeat Intravitreal Injections of GEM103 in Dry Age-related Macular Degeneration

NCT04643886

This study is designed to investigate the safety, PK/PD, biomarker and early clinical effects of repeat GEM103 IVT injections.

Dry Age-related Macular DegenerationGeographic AtrophyMacular Degeneration+2 more

Gemini Therapeutics, Inc.62 participantsStarted Jul 2020

Phoenix, Arizona, United States • Bakersfield, California, United States • Beverly Hills, California, United States +26 more locations

COMPLETEDPhase 324 miles

A Phase III Study to Evaluate the Port Delivery System With Ranibizumab Compared With Monthly Ranibizumab Injections in Participants With Wet Age-Related Macular Degeneration

NCT03677934

Study GR40548 is a Phase III, randomized, multicenter, open-label (visual assessor \[VA\]-masked), active-comparator study designed to assess the efficacy, safety, and pharmacokinetics (PK) of 100mg/ml delivered via the Port Delivery System with ranibizumab (PDS) compared with ranibizumab intravitreal injections at 0.5 mg (10 mg/mL) in participants with neovascular age-related macular degeneration (nAMD).

Neovascular Age-Related Macular Degeneration

Hoffmann-La Roche415 participantsStarted Sep 2018

Mesa, Arizona, United States • Phoenix, Arizona, United States • Phoenix, Arizona, United States +74 more locations

UNKNOWN26 miles

OEIS Outcome Data Registry

NCT03058913

This registry is created under the sponsorship of the Outpatient Endovascular and Interventional Society (OEIS) to monitor the clinical course and treatment outcomes of patients undergoing office-based endovascular procedures.

Peripheral Arterial Disease

Outpatient Endovascular and Interventional Society600,000 participantsStarted Feb 2017

Hoffman Estates, Illinois, United States

COMPLETEDPhase 281 miles

A Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Chronic Migraine Prevention

NCT02066415

To evaluate the effect of erenumab compared to placebo on the change from baseline in the number of monthly migraine days in adults with chronic migraine.

Treatment for Prevention of Chronic Migraine

Amgen667 participantsStarted Mar 2014

La Jolla, California, United States • Newport Beach, California, United States • San Francisco, California, United States +71 more locations

COMPLETEDPhase 2165 miles

Study of Romosozumab (AMG 785) in Tibial Diaphyseal Fractures Status Post Intramedullary Nailing

NCT00907296

The primary objective of this study is to investigate the effect of romosozumab compared with placebo on time to radiographic healing of fresh tibial diaphyseal fractures (fractures in the midsection of the shinbone).

Fracture Healing

Amgen402 participantsStarted Sep 2009

Birmingham, Alabama, United States • Orange, California, United States • Aurora, Colorado, United States +100 more locations

COMPLETEDPhase 3254 miles

Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Migraine Prevention

NCT02456740

The primary objective of the study was to evaluate the effect of erenumab compared to placebo on the change from baseline in monthly migraine days.

Amgen955 participantsStarted Jul 2015

Phoenix, Arizona, United States • Anaheim, California, United States • Encino, California, United States +126 more locations

TERMINATEDPhase 1262 miles

Study of AZD5991 Alone or in Combination With Venetoclax in Relapsed or Refractory Haematologic Malignancies.

NCT03218683

This study is a multicenter, open-label, nonrandomized, sequential group, dose-escalation study to assess safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of ascending doses of AZD5991 in subjects with relapsed or refractory hematologic malignancies Part 1 of the study is monotherapy dose escalation. Closed November 2020 Part 2 of the study is monotherapy expansion groups for relapsed/refractory chronic lymphocytic leukaemia (CLL), AML/ myelodysplastic syndromes (MDS), and multiple myeloma (MM). Closed November 2020 Part 3 is a sequential, dose-escalation study of the combination of AZD5991 and venetoclax in subjects with relapsed/refractory AML

Relapsed or Refractory Acute Myeloid Leukemia (AML)

AstraZeneca70 participantsStarted Aug 2017

Orange, California, United States • Aurora, Colorado, United States • Atlanta, Georgia, United States +7 more locations

RECRUITING269 miles

Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry

NCT04669548

The Accuryn Registry Study is an open-ended, global, multi-center, retrospective and prospective, single-arm data collection study with an FDA cleared device. The target population are cardiovascular surgery patients. Physiologic data measurements will be collected from enrolled subjects using electronic medical records and data streams via the Accuryn Monitoring System.

Intraabdominal HypertensionAbdominal Compartment SyndromeAcute Kidney Injury+1 more

Potrero Medical2,500 participantsStarted Dec 2020

Los Angeles, California, United States • San Francisco, California, United States • Washington D.C., District of Columbia, United States +6 more locations

COMPLETEDNA355 miles

FILtration of Subarachnoid Hemorrhage Via SpinaL CAtheteR Extension

NCT03607825

The objective of this study is to further demonstrate safety and characterize effectiveness of the Neurapheresis™ System (extracorporeal system and catheter) to remove red blood cells (RBCs) and lysed blood by-products from hemorrhagic cerebrospinal fluid (CSF) following aneurysmal subarachnoid hemorrhage (aSAH).

Subarachnoid Hemorrhage

Minnetronix33 participantsStarted Dec 2018

Gainesville, Florida, United States • Minneapolis, Minnesota, United States • New York, New York, United States +1 more locations

COMPLETEDNA1742 miles

Long-Term Retention of Gadolinium in Bone

NCT01853163

The main objective was to prospectively explore the potential for long-term retention of Gadolinium (Gd) in bones in patients who have received a single dose of Gadolinium-based contrast agents (GBCA) or multiple doses of the same GBCA, with moderate or severe renal impairment or stable normal renal function (eGFR \> 60 ml/min/1.73 m2) at the time of GBCA injection.

Focus: Long-term Retention of Gadolinium-based Contrast Agent

Navitas Life Sciences GmbH92 participantsStarted May 2013

Los Angeles, California, United States • Halle, Germany • Magdeburg, Germany +13 more locations

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