Parkinson's Disease Clinical Trials

Showing 141-160 of 1,818 trials

Retrospective Observational Study of Blood-based Biomarkers in the Diagnosis and Monitoring of Patients With a Neurodegenerative Disease or Mental Disorder

NCT07314190

This is a retrospective observational study to evaluate the clinical utility of blood-based biomarkers in the diagnosis and management of patients with a neurodegenerative disease (ND) or mental disorder (MD).

Alzheimer DiseaseDementia With Lewy Bodies (DLB)Frontotemporal Dementia (FTD)+4 more

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau1,799 participantsStarted Feb 2026

Barcelona, Spain

Not Yet RecruitingNA

Double-Blind Clinical Trial of Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease

NCT06008717

The goal of this trial is to evaluate the preliminary safety and efficacy of programming to maximize stimulation of the dorsolateral region of the subthalamic nucleus (STN) receiving primary motor (M1) and supplementary motor area (SMA), but not pre-SMA, input deep brain stimulation (DBS) in patients with early-stage Parkinson's disease (PD).

Parkinson Disease

Mallory Hacker40 participantsStarted Jan 2028

RECRUITINGNA

Aquatic High-Intensity Interval Training for Parkinson's Disease

NCT07264114

This randomized, single-center, parallel-group superiority trial will evaluate the effect of an 8-week aquatic High-Intensity Interval Training (HIIT) program on balance, physical function, and sarcopenia-related outcomes in individuals with Parkinson's disease (PD). The intervention aims to deliver Tabata-style aquatic HIIT (3 sessions/week) in a therapeutic pool to determine adherence and preliminary efficacy compared with standard care (no structured exercise program).

Parkinson Disease

Pardis Specialized Wellness Institute56 participantsStarted Dec 2025

Isfahan, Iran

Retrospective Observational Study of Blood-based Biomarkers in the Diagnosis and Monitoring of Patients With a Neurodegenerative Disease or Mental Disorder

Double-Blind Clinical Trial of Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease

Aquatic High-Intensity Interval Training for Parkinson's Disease

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LIFUS For Neurological Disorders

Understanding Freezing of Gait Using Brain Signals and Virtual Reality

Low Intensity Focused Ultrasound for Parkinson's Disease

Vestibulopathy, Imbalance, and Gait Disturbances in Parkinson Disease

Detection of Internal Tremors by Oscillometry in Parkinson's Patient

Repetitive Transcranial Magnetic Stimulation for Musculoskeletal Pain in Patients With Parkinson's Disease

Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Real-World Study of Foslevodopa/Foscarbidopa to Assess Quality of Life Outcomes in Adult Participants Earlier Within Advanced Parkinson Disease

Neurophysiology of Reward Signaling in Parkinson's Disease

Optimistic and Pessimistic Dopamine Signals in the Human Brain: a Mapping and Modelling Study in Health and Parkinson's Disease

Speech Learning and Speech Production in Parkinson's Disease

Quantification of Phosphorylated Alpha-synuclein in Cutaneous Biopsies as a Prospective Biomarker in Parkinson's Disease

Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder

Home-Based Calligraphic Handwriting Exercises in Parkinson's Disease

Accelerated TMS for Apathy in PD

Medico-economic Evaluation Rehabilitation by Serious Games at Home for the Management of Patients With Parkinson's Disease Suffering From Gait and Balance Disorders

Retinal Imaging in Neurodegenerative Disease