Multiple Sclerosis Clinical Trials

Showing 161-180 of 5,959 trials

AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors

NCT07403721

The primary objectives of this trial are to evaluate the safety profile of AMG 436 and to determine the maximum tolerated dose (MTD) and/or the recommended dose for AMG 436 as monotherapy and in combination with other anti-cancer therapies in participants with MSI-H/dMMR solid tumors.

Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR)

Amgen464 participantsStarted Apr 2026

Irving, Texas, United States • Melbourne, Victoria, Australia • Shanghai, Shanghai Municipality, China +3 more locations

RECRUITINGNA

Brain Activity Among Children With Overactive Bladder and Daytime Urinary Incontinence and Healthy Children

NCT05989646

The aim of this study is to investigate whether the activity in brain areas controlling the bladder is different among children suffering from Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI) compared to age- and gender-matched healthy children without bladder symptoms. Moreover, the aim is to investigate if sacral transcutaneous electric nerve stimulation (TENS) has a central mechanism of action. Children with OAB and DUI will be recruited from involved pediatric departments, and functional magnetic resonance imaging (fMRI) will be performed before and after 10 weeks of sacral TENS. In healthy children without bladder symptoms, only the baseline fMRI will be performed.

Urinary IncontinenceDaytime WettingUrination Disorders+7 more

Aalborg University Hospital65 participantsStarted May 2021

Aalborg, Denmark • Aarhus, Denmark • Herning, Denmark +1 more locations

AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors

Brain Activity Among Children With Overactive Bladder and Daytime Urinary Incontinence and Healthy Children

Related Searches

M7824 Related Adverse Effects in Adults With Cancer

A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors

Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia

Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

SBRT Followed by PD-1 Inhibitor, Bevacizumab and TAS-102 as Third-Line Therapy for Recurrent/Metastatic Colorectal Cancer

Definition of Autonomic Nervous System Involvement in Patients With Multiple Sclerosis

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Cystic Neoplasms and Pancreatic Neuroendocrine Tumors

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Assessment of Probe Based Confocal Laser Endo-microscopy for In-vivo Diagnosis of Peripheral Lung Nodules and Masses.

Impact of Intraoperative PTCD Catheter Retention Versus Removal on Postoperative Short-term Outcomes After Pancreaticoduodenectomy in Obstructive Jaundice

A Phase II Study Evaluating BMS-986504 in MTAP-deleted Pancreatic Cancer

Agnostic Therapy in Rare Solid Tumors

Dyadic Yoga Intervention for Patient With Head and Neck Cancer Undergoing Radiotherapy and Their Family Caregivers

Dynamic Stretching vs. Foam Rolling: Effects on Hamstring Flexibility and Muscle Oxygenation in Tight Hamstrings

Selumetinib and Olaparib in Solid Tumors

n-3 PUFAs, Irisin and Maternal Glucose Metabolism From Pregnancy to Postpartum