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Browse 5,960 clinical trials for multiple sclerosis. Find studies that match your criteria and connect with research centers.
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Showing 4621-4640 of 5,960 trials
NCT01680328
This trial is conducted in Europe. The aim of this trial is to assess and describe the pain in relation to subcutaneous (under the skin) injection of different combinations of injection speed and volume with respect to acceptance of the injection pain and backflow.
NCT02216669
This is a Phase I multicenter, open-label, dose-escalation study of DTP348. DTP 348 is an oral dual drug with two mechanisms of action: 1. carbonic anhydrase IX inhibitor which acidifies the intracellular pH through the sulfamide components 2. radio sensitizer of hypoxic cells through its 5-nitroimidazole moiety The study will be conducted in 2 parts. The phase I trials will be on the standard 3+3 design first as single agent then combined with radiotherapy: 1. A single agent dose-escalation phase in patients with solid tumours. 2. A dose-escalation phase in patients with HNSCC in combination with radiotherapy The main objective is to determine the recommended phase II dose of DTP348 in combination with radiotherapy
NCT01576380
This is a prospective, open-label, single-arm, non-randomized, multi-center, phase II proof of concept (PoC) study with a two-stage design and Bayesian interim monitoring to evaluate efficacy and safety of single agent TKI258 in adult patients with scirrhous gastric carcinoma (SGC) that have progressed after one or two prior systemic treatments.