Multiple Sclerosis Clinical Trials

Showing 3301-3320 of 5,960 trials

Identifying Immune-related Biomarkers to Predict the Efficacy of Cancer Immunotherapy

NCT03595813

The development of Immune Checkpoint Blockade (ICB) is a revolution in medical oncology as ICB have changed the standard treatments of several metastatic tumor types. However, the response rate to ICB is low, and the biological bases for this response heterogeneity are poorly understood. In the frame of Immunosup study, we will collect blood (at baseline, post infusion of ICB n°2/4/8 and at progression) and tumor samples (optional: at baseline and progression) from patients with locally advanced or metastatic cancer, treated with ICB, in order to determine if the dynamics of immunosuppressive actors (MDSC, TReg, Immunosuppressive cytokines) predicts response to these immunotherapies.

Lung Cancer MetastaticLocally Advanced Malignant NeoplasmNon Hodgkin Lymphoma+1 more

Institut Paoli-Calmettes135 participantsStarted Jan 2018

Marseille, Bouches-du-Rhône, France

COMPLETEDEARLY Phase 1

ET1402L1-ARTEMIS™2 T Cells in Alpha Fetoprotein (AFP) Expressing Hepatocellular Carcinoma

NCT03888859

Clinical study to evaluate safety (primary objectives) and efficacy (secondary objective) of ET1402L1-ARTEMIS™2 T cells in patients with alpha fetoprotein positive (AFP+ ) hepatocellular carcinoma (HCC).

Hepatocellular CarcinomaLiver CancerLiver Neoplasms+1 more

First Affiliated Hospital Xi'an Jiaotong University12 participantsStarted Dec 2017

Xi'an, China

Identifying Immune-related Biomarkers to Predict the Efficacy of Cancer Immunotherapy

ET1402L1-ARTEMIS™2 T Cells in Alpha Fetoprotein (AFP) Expressing Hepatocellular Carcinoma

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