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Clareo Health | Melanoma Clinical Trials in North Carolina | 52 Studies

Clinical Trials MelanomaNorth Carolina

Melanoma Clinical Trials in North Carolina

Find 52 clinical trials for melanoma near North Carolina. Connect with research centers in your area.

All Melanoma trials nationwide All trials in North Carolina

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Status

RecruitingNot yet recruitingActive, not recruitingEnrolling by invitationCompletedTerminated

Phase

Early phase 1Phase 1Phase 1–2Phase 2Phase 2–3Phase 3Phase 4Not applicable

Who can join

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Showing 21-40 of 52 trials

Active not recruitingA Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid TumorsTScan Therapeutics is developing cellular therapies across multiple solid tumors in which autologous participant-derived engeneered T cells are engineered to express a T cell…NCT05973487·Scottsdale, Arizona and 20 others

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Data from ClinicalTrials.govTerms

TerminatedElesclomol (STA-4783) With Paclitaxel Versus Paclitaxel Alone in Melanoma"Elesclomol (STA-4783), N-malonyl-bis (N'-methyl-N'-thiobenzoylhydrazide) is a new chemical entity with a novel structure. STA-4783 induces an oxidative stress response in cells.NCT00522834·Tucson, Arizona and 100 others

CompletedS0508: Thalidomide and Temozolomide in Treating Patients With Stage IV Melanoma That Cannot Be Removed By SurgeryRATIONALE: Thalidomide may stop the growth of melanoma by blocking blood flow to the tumor.NCT00104988·Anchorage, Alaska and 131 others

Active not recruitingTesting Two Different Treatment Schedules of Dabrafenib and Trametinib for Skin Cancer Which Has SpreadThis phase II trial compares the effect of dabrafenib and trametinib given continuously to given with a break in treatment (intermittent) in treating patients with stage III-IV…NCT02196181·Birmingham, Alabama and 751 others

CompletedLCCC 1128: Open Label Phase II Trial of the BRAF Inhibitor (Dabrafenib) and the MEK Inhibitor (Trametinib) in Unresectable Stage III and Stage IV BRAF Mutant Melanoma; Correlation of Resistance With the Kinome and Functional MutationsThis phase II study in 20 patients with BRAFV600E mutant, unresectable stage III/IV melanoma is designed to explore the mechanisms by which tumors acquire resistance to the…NCT01726738·Chapel Hill, North Carolina

Active not recruitingNBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 TherapyThe 1100 study is an open-label, Phase I, dose escalation and expansion prospective clinical study to assess the safety of intratumoral injection of NBTXR3 activated by…NCT03589339·San Francisco, California and 12 others

TerminatedGamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV MelanomaThis phase II trial is studying how well gamma-secretase/Notch signalling pathway inhibitor RO4929097 works in treating patients with stage IV melanoma.NCT01120275·Mobile, Alabama and 177 others

CompletedCarboplatin and Paclitaxel With or Without Sorafenib Tosylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by SurgeryThis randomized phase III trial studies carboplatin, paclitaxel, and sorafenib tosylate to see how well they work compared to carboplatin and paclitaxel in treating patients with…NCT00110019·Birmingham, Alabama and 218 others

CompletedCarboplatin and ABI-007 in Treating Patients With Stage IV Melanoma That Cannot Be Removed By SurgeryRATIONALE: Drugs used in chemotherapy, such as carboplatin and ABI-007, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them…NCT00404235·Scottsdale, Arizona and 155 others

RecruitingComparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage MelanomaThis phase III trial compares the effect of wide local excision (WLE) alone to usual care with WLE plus sentinel lymph node (SLN) biopsy for the treatment of older adults with…NCT07068074·Birmingham, Alabama and 180 others

CompletedEfficacy Study of Pharmacokinetic(PK)/Pharmacodynamic(PD) Relationship of Monotherapy MORAb-004 in Metastatic MelanomaThis is a global, Phase 2, open label, dose selection, proof-of-concept study to assess progression free survival in subjects with metastatic melanoma.NCT01335009·Scottsdale, Arizona and 28 others

CompletedSargramostim, Vaccine Therapy, or Sargramostim and Vaccine Therapy in Preventing Disease Recurrence in Patients With Melanoma That Has Been Removed By SurgeryThis randomized phase III trial studies sargramostim or vaccine therapy alone to see how well they work compared to sargramostim and vaccine therapy together in preventing disease…NCT01989572·Birmingham, Alabama and 147 others

TerminatedStudy of a Melanoma Vaccine in Stage IIb, IIc, and III Melanoma PatientsThe purpose of this study is to determine how safe and how well POL-103A works in preventing the relapse of melanoma after patients who have undergone surgery.NCT01546571·Chandler, Arizona and 64 others

Active not recruitingTargeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)This phase II MATCH screening and multi-sub-trial studies how well treatment that is directed by genetic testing works in patients with solid tumors, lymphomas, or multiple…NCT02465060·Birmingham, Alabama and 1409 others

RecruitingA First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their BodyThis study is researching an experimental drug called REGN10597 alone or in combination with another drug called cemiplimab (called "study drug(s)").NCT06413680·Los Angeles, California and 10 others

Active not recruitingDabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 MelanomaThis phase III trial studies how well initial treatment with ipilimumab and nivolumab followed by dabrafenib and trametinib works and compares it to initial treatment with…NCT02224781·Birmingham, Alabama and 837 others

CompletedBevacizumab and Temozolomide or Bevacizumab and Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin in Treating Patients With Stage IV Malignant Melanoma That Cannot Be Removed by SurgeryRATIONALE: Drugs used in chemotherapy, such as temozolomide, paclitaxel albumin-stabilized nanoparticle formulation, and carboplatin, work in different ways to stop the growth of…NCT00626405·Anchorage, Alaska and 258 others

CompletedEverolimus in Treating Patients With Stage IV MelanomaRATIONALE: Drugs used in chemotherapy, such as everolimus, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.NCT00098553·Scottsdale, Arizona and 93 others

Active not recruitingIpilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by SurgeryThis randomized phase III trial studies ipilimumab to see how well it works compared to high-dose interferon alfa-2b in treating patients with high-risk stage III-IV melanoma that…NCT01274338·Birmingham, Alabama and 936 others

Active not recruitingPhase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer TherapiesThis is a multi-center, open-label Phase 0 Master Protocol designed to study the localized pharmacodynamics (PD) of anti-cancer therapies within the tumor microenvironment (TME)…NCT04541108·Shreveport, Louisiana and 8 others

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Breast Cancer Lung Cancer Prostate Cancer Colorectal Cancer Leukemia Lymphoma