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Browse 1,471 clinical trials for lupus. Find studies that match your criteria and connect with research centers.
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NCT04726982
Acetazolamide, a carbonic anhydrase inhibitor, has received some attention as potential treatment for obstructive sleep apnea (OSA). It produces a metabolic acidosis by excreting bicarbonate, thereby stimulating baseline ventilation. Evidence suggests that acetazolamide primarily improves ventilatory control instability (expressed as loop gain), which is an important contributor to the pathophysiology of OSA. Few studies have assessed the efficacy of acetazolamide in patients with OSA. Since most of them had a small sample size and used different therapeutic dosages, clinical applications are currently limited. Therefore, this study aims to compare the effect of two acetazolamide dosages on the severity and pathophysiology of OSA.
NCT07188831
Hospital staff often experience workplace fatigue and poor sleep quality, which can harm their health, reduce job performance, and increase risks to patient safety. Aromatherapy is a simple, non-invasive complementary therapy that may help reduce fatigue and improve sleep. Agarwood (Aquilaria spp.) has calming and relaxing properties, but there is little clinical research on its effectiveness for hospital staff. This randomized, double-blind, controlled trial will evaluate whether agarwood aromatherapy inhalation can improve fatigue and sleep quality among hospital employees in Taiwan. About 78 participants will be recruited and randomly assigned to one of two groups: 1. Experimental group: Agarwood sachet containing agarwood wood chips and essential oil. 2. Control group: Placebo sachet containing almond oil. Participants will place the sachet about 60 cm from the nose during sleep for 7 nights. Data will be collected using questionnaires on workplace fatigue and sleep quality (Pittsburgh Sleep Quality Index, PSQI). The main questions this study aims to answer are: 1. Does agarwood aromatherapy reduce workplace fatigue in hospital staff? 2. Does agarwood aromatherapy improve sleep quality compared with placebo? Findings are expected to provide scientific evidence for using agarwood inhalation as a safe and convenient strategy to improve staff well-being and support a healthier hospital environment.