Lupus Clinical Trials

Showing 201-220 of 1,471 trials

The Effect of Thalamic Stimulation on Sleep Oscillations

NCT07217080

The thalamus plays a key role in supporting sleep and is also a target of therapeutic stimulation. This project investigates when, where, and how electrical stimulation delivered to the thalamus in humans elicits or disrupts sleep oscillations. This research is a first step to better understand how current neuromodulation therapies affect sleep and may help advance toward new therapies to improve sleep for a wide range of neurological and neuropsychological disorders.

SleepNeuromodulation

Massachusetts General Hospital50 participantsStarted Jan 2025

Boston, Massachusetts, United States • Boston, Massachusetts, United States

COMPLETED

Impact of Iron Supplementation Treatment on Brain Iron Concentrations

NCT04144790

The goal of the present study is to provide novel data to evaluate brain iron concentration as a mediator of the association between iron supplementation treatment and improvement in symptoms of ADHD and RLS in children, including PLMS. Twelve participants between the ages of 10 and 15 years will be recruited via Kennedy Krieger Institute's Sleep Disorders Clinic. Eligible participants will be asked to complete, at baseline (pre-iron supplementation treatment) and again at follow-up (post-treatment): 1) a 7 Tesla MRI scan, 2) five consecutive nights of RestEaZe™ monitoring, 3) caregiver-reported (or patient-reported if over the age of 10 years) International Restless Leg Syndrome Scale (IRLSS), and 4) caregiver-reported ADHD Rating Scale-5. The treatment interval will be 3 months.

ADHDIron-deficiencyRestless Legs Syndrome+1 more

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.12 participantsStarted Sep 2022

Baltimore, Maryland, United States

The Effect of Thalamic Stimulation on Sleep Oscillations

Impact of Iron Supplementation Treatment on Brain Iron Concentrations

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